Indian Journal of Critical Care Medicine
An open access publication of ISCCM™ 
 
Users online: 45 
     Home | Login 
  About Current Issue Archive Search Instructions Online Submission Subscribe Etcetera Contact  
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2301    
    Printed178    
    Emailed1    
    PDF Downloaded505    
    Comments [Add]    
    Cited by others 12    

Recommend this journal

 

 RESEARCH ARTICLE
Year : 2011  |  Volume : 15  |  Issue : 2  |  Page : 108--113

Efficacy and safety of parenteral omega 3 fatty acids in ventilated patients with acute lung injury


Department of Intensive Care Medicine, Artemis Health Institute, Sector 51, Gurgaon, Haryana, India

Correspondence Address:
Ajay Gupta
Department of Intensive Care Medicine, 6A/47 Wea, Karol Bagh, New Delhi - 110 005
India
Login to access the Email id


DOI: 10.4103/0972-5229.83019

PMID: 21814375

Get Permissions

Objective : To determine the effects of parenteral omega 3 fatty acids (10% fatty acids) on respiratory parameters and outcome in ventilated patients with acute lung injury. Measurements and Main Results : Patients were randomized into two groups - one receiving standard isonitrogenous isocaloric enteral diet and the second receiving standard diet supplemented with parenteral omega 3 fatty acids (Omegaven, Fresenius Kabi) for 14 days. Patients demographics, APACHE IV, Nutritional assessment and admission category was noted at the time of admission. No significant difference was found in nutritional variables (BMI, Albumin). Compared with baseline PaO 2 /FiO 2 ratio (control vs. drug group: 199 ± 124 vs. 145 ± 100; P = 0.06), by days 4, 7, and 14, patients receiving the drug did not show a significant improvement in oxygenation (PaO 2 /FiO 2 : 151.83 ± 80.19 vs. 177.19 ± 94.05; P = 0.26, 145.20 ± 109.5 vs. 159.48 ± 109.89; P = 0.61 and 95.97 ± 141.72 vs. 128.97 ± 140.35; P = 0.36). However, the change in oxygenation from baseline to day 14 was significantly better in the intervention as compared to control group (145/129 vs. 199/95; P < 0.0004). There was no significant difference in the length of ventilation (LOV) and length of ICU stay (LOS). There was no difference in survival at 28 days. Also, there was no significant difference in the length of ventilation and ICU stay in the survivors group as compared to the non survivors group. Conclusions : In ventilated patients with acute respiratory distress syndrome, intravenous Omega 3 fatty acids alone do not improve ventilation, length of ICU stay, or survival.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 7th April '04
Published by Medknow