Advertisment Polium-B
Indian Journal of Critical Care Medicine
An open access publication of ISCCM™ 
 
Users online: 2063 
     Home | Login 
  About Current Issue Archive Search Instructions Online Submission Subscribe Etcetera Contact  
  NAVIGATE Here 
  Search
 
  
 RESOURCE Links
 »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »  Article in PDF (529 KB)
 »  Citation Manager
 »  Access Statistics
 »  Reader Comments
 »  Email Alert *
 »  Add to My List *
* Registration required (free) 

  IN THIS Article
 »  Abstract
 » Introduction
 » Case Report
 » Discussion
 »  References
 »  Article Figures
 »  Article Tables

 Article Access Statistics
    Viewed1043    
    Printed27    
    Emailed0    
    PDF Downloaded235    
    Comments [Add]    
    Cited by others 1    

Recommend this journal

 


 
 Table of Contents    
CASE REPORT
Year : 2014  |  Volume : 18  |  Issue : 12  |  Page : 825-827

Acute airway obstruction due to spontaneous intrathyroid hemorrhage precipitated by anticoagulation therapy


1 Department of Family Medicine, University of Arkansas for Medical Science, Arkansas, USA
2 Department of Pulmonary and Critical Care, University of Arkansas for Medical Science, Arkansas, USA

Date of Web Publication5-Dec-2014

Correspondence Address:
Dr. Laxmi Kokatnur
Department of Family Medicine, 601 Napa Valley Drive, Apartment 234, Little Rock, Arkansas 72211
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-5229.146324

Rights and Permissions


 » Abstract 

Acute airway compromise due to hemorrhage in of thyroid gland is a rare life-hreating condition. The increasing use of anticoagulants for various reasons is likely increased the occurrence of this this complication. We describe an elderly patient on anticoagulation for atrial fibrillation, which developed swelling on the right side of neck causing acute airway obstruction requiring emergency intubation for airway protection. Computed tomographic scan showed massive intrathyroid hemorrhage along with substernal extension. She had supratherapeutic INR which was appropriately corrected emergently. She underwent resection of the thyroid gland which showed multinodular goiter without any evidence of malignancy. Our case illustrates the rare but lethal bleeding complication of anticoagulants in critical anatomical area and we request physicians should be wary of similar conditions.


Keywords: Airway obstruction, anticoagulation, hyperthyroidism, substernal goitre, thyroid hemorrhage


How to cite this article:
Kokatnur L, Rudrappa M, Mittadodla P. Acute airway obstruction due to spontaneous intrathyroid hemorrhage precipitated by anticoagulation therapy. Indian J Crit Care Med 2014;18:825-7

How to cite this URL:
Kokatnur L, Rudrappa M, Mittadodla P. Acute airway obstruction due to spontaneous intrathyroid hemorrhage precipitated by anticoagulation therapy. Indian J Crit Care Med [serial online] 2014 [cited 2018 Jul 17];18:825-7. Available from: http://www.ijccm.org/text.asp?2014/18/12/825/146324



 » Introduction Top


Bleeding in vital areas of the body such as the neck can be life-threatening due to a sudden compromise in breathing. Despite being highly vascularized, thyroid hemorrhage leading to airway compromise is uncommon and occurs following trauma, fine-needle aspiration and malignancy. [1] Spontaneous bleeding due to concomitant use of anticoagulants is very rare, and only few case reports have been published. Preexisting benign conditions such as goiter, which occurs in 4% of adults will lead to increase vascularity of the gland and can increase the risk of bleeding. Patients on anticoagulants therapy have been increasing, and approximately 4.2 million Americans are on these medications currently. [2] The risk of bleeding due to goiter induced increased capillarity precipitated by increased use of anticoagulants can cause massive hemorrhage and sudden unexpected airway compromise. We present a case of spontaneous thyroid hemorrhage that was timely recognized and treated.


 » Case Report Top


The patient is a 73-year-old white female with a history of atrial fibrillation on warfarin therapy presented with complaints of fever, burning micturition, and abdominal pain. She was admitted at a community hospital for the treatment of complicated urinary tract infection. She was started on levofloxacin, intravenous fluids and continued on warfarin. After 3 days, she started having difficulty in breathing. Chest X-ray showed prominent pulmonary vasculature, and she was treated for congestive heart failure. The next day, she developed some difficulty in swallowing and underwent bedside swallow study, which showed oropharyngeal dysphagia. By the evening, she developed severe neck pain and noticed sudden swelling on the right side of her neck. In view of worsening respiratory distress, urgent computed tomographic of the neck was done, which showed hemorrhage in the thyroid gland with retrosternal extension along with significant deviation and compression of the trachea [Figure 1]. Emergent intubation with Fr 6 endotracheal tube was done and was transferred to our institute for further management.
Figure 1: Axial and coronal computed tomographic scan image showing intrathyroidal hemorrhage causing compression and deviation of the trachea (blue arrows)

Click here to view


On the presentation, her INR had increased to three, immediately corrected with four units of fresh frozen plasma and was continued on mechanical ventilation with sedation protocol. She was seen by ENT services and underwent biopsy of the thyroid gland to rule out any underlying malignancy. Even with anticoagulant therapy, spontaneous hemorrhage is considered rare, and the presence of underlying malignancy would definitely change her management. Her biopsy specimen showed nodular goiter with bleeding and no evidence of malignancy. Later, she underwent median sternotomy and excision of retrosternal goiter with combined collaboration of ENT and thoracic surgeons. During surgery, the thyroid gland was observed as extending up to the level of the innominate vein.

She continued to be febrile, tachycardic, and diaphoretic with elevated T4 levels, which was indicative of hyperthyroidism [Table 1]. Because she was scheduled for elective major surgery, antithyroid medications were initiated for control of increase sympathetic activity. As expected, following surgery she developed hypothyroidism and was started on thyroid supplements. She was discharged in a stable condition to the sub-acute rehabilitation facility and is presently doing well at the time of this writing.
Table 1: Levels of thyroid hormones before and after the
surgery showing features of hyper and hypo thyroidism
respectively


Click here to view



 » Discussion Top


Thyroid is one of the most highly vascularized organs of the body; however, spontaneous thyroid hemorrhage has been rarely reported only as case reports following trauma or fine-needle aspiration cytology and spontaneous bleeding with or without the use of antihemostatic agents. [1],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12] Pre-existing conditions like thyroid malignancy or colloid goiter can increase the risk of bleeding due to increased and altered vascularity. The source of bleeding is usually venous due to rupture of vessels with deficient adventitia, musculature, and elastic tissue. [13] The capsule is highly vascular and has many anastomotic channels with the penetrating vessels supplying core of the nodule. Physical exertion, coughing, straining, or any valsalva maneuver that increases venous pressure can cause rupture of these vessels leading to spontaneous bleeding. [13]

Although the use of iodized salt has reduced the incidence of goiter in the United States, up to 25% of the population continues to develop thyroid enlargement. [14] With the increase in the population size of the elderly, the incidence of atrial fibrillation and the use of anticoagulants are rising, and at present, 4.2 million individuals are on anticoagulation medications. [2],[15] In large clinical trials, bleeding rates due to the use of warfarin are 18.15%, 14.5%, and 25.8%, with major bleeding constituting 3.36%, 3.4%, and 3.4%, respectively. [16],[17],[18] In the real world, however the incidence of bleeding is lower, at approximately 9.6% of the total bleeding rate, which is also supported by postmarketing analysis of these major trials. [19] As thyroid hemorrhage is not captured in any of these trials, the true incidence of thyroid hemorrhage is not known. [20] To date, only two cases of thyroid hemorrhage due to warfarin have been described in the literature. [1],[8] . With more than 5% of the population with goiter on warfarin, these two cases, along with our case, might only be representing the tip of the iceberg.

Hemorrhage to the thyroid gland can cause sudden compression of the trachea and if more than two-third of the lumen is compressed than it can lead to sudden upper airway obstruction warranting emergency intubation. Furthermore, if the bleeding is not controlled; the patient will need emergency thyroidectomy. [21] Bleeding into the gland can cause a sudden release of preformed thyroid hormones leading to acute hyperthyroidism. [9],[22],[23],[24],[ 25] This rare cause of destructive hyperthyroidism is usually self-limiting and does not require any treatment. However, most patients require emergency thyroidectomy and eventually develop hypothyroidism.

Our report describes the third case of thyroid hemorrhage in the literature and reiterates the risk of spontaneous intrathyroid hemorrhage and the potential life-treating complication due to airway compromise in patients taking warfarin. Early recognition and timely intervention could be lifesaving.

 
 » References Top

1.
Tsilchorozidou T, Vagropoulos I, Karagianidou C, Grigoriadis N. Huge intrathyroidal hematoma causing airway obstruction: A multidisciplinary challenge. Thyroid 2006;16:795-9.  Back to cited text no. 1
    
2.
Beauregard K. Outpatient Prescription Anticoagulants Utilization and Expenditures for the U.S. Civilian Noninstitutionalized Population Age 18 and Older. Statistical Brief #268. Agency for Healthcare Research and Quality; October, 2009.  Back to cited text no. 2
    
3.
Chang CC, Chou YH, Tiu CM, Chiou HJ, Wang HK, Chiou SY, et al. Spontaneous rupture with pseudoaneurysm formation in a nodular goiter presenting as a large neck mass. J Clin Ultrasound 2007;35:518-20.  Back to cited text no. 3
    
4.
Hor T, Lahiri SW. Bilateral thyroid hematomas after fine-needle aspiration causing acute airway obstruction. Thyroid 2008;18:567-9.  Back to cited text no. 4
    
5.
Armstrong WB, Funk GF, Rice DH. Acute airway compromise secondary to traumatic thyroid hemorrhage. Arch Otolaryngol Head Neck Surg 1994;120:427-30.  Back to cited text no. 5
    
6.
Blaivas M, Hom DB, Younger JG. Thyroid gland hematoma after blunt cervical trauma. Am J Emerg Med 1999;17:348-50.  Back to cited text no. 6
    
7.
Weeks C, Moore FD Jr, Ferzoco SJ, Gates J. Blunt trauma to the thyroid: A case report. Am Surg 2005;71:518-21.  Back to cited text no. 7
    
8.
Lee JK, Lee DH, Cho SW, Lim SC. Acute airway obstruction by spontaneous hemorrhage into thyroid nodule. Indian J Otolaryngol Head Neck Surg 2011;63:387-9.  Back to cited text no. 8
    
9.
Olchovsky D, Pines A, Zwas ST, Itzchak Y, Halkin H. Apathetic thyrotoxicosis due to hemorrhage into a hyperfunctioning thyroid nodule after excessive anticoagulation. South Med J 1985;78:609-11.  Back to cited text no. 9
    
10.
Roh JL. Intrathyroid hemorrhage and acute upper airway obstruction after fine needle aspiration of the thyroid gland. Laryngoscope 2006;116:154-6.  Back to cited text no. 10
    
11.
Testini M, Gurrado A, Lissidini G, Lardo D, Poli E, Piccinni G. Emergency surgery for acute respiratory failure secondary to spontaneous thyroid hemorrhage. Int Surg 2008;93:158-62.  Back to cited text no. 11
    
12.
Gallant SC, Fritz MA, Paul BC, Costantino PD. Management of airway compromise following thyroid cyst hemorrhage after thrombolytic therapy. Laryngoscope 2014.  Back to cited text no. 12
    
13.
Testini M, Logoluso F, Lissidini G, Gurrado A, Campobasso G, Cortese R, et al. Emergency total thyroidectomy due to non traumatic disease. Experience of a surgical unit and literature review. World J Emerg Surg 2012;7:9.  Back to cited text no. 13
    
14.
Kelly FC, Snedden WW. Prevalence and Geographical Distribution of Endemic Goiter. WHO Pulication Monogram 44. 2003. [AOI:6276176]. Available from: http://www.whqlibdoc.who.int/monograph/WHO_MONO_44_(p27)_(part1).pdf. Last accessed in July 15 th 2014.  Back to cited text no. 14
    
15.
Colilla S, Crow A, Petkun W, Singer DE, Simon T, Liu X. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am J Cardiol 2013;112:1142-7.  Back to cited text no. 15
    
16.
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361:1139-51.  Back to cited text no. 16
    
17.
Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365:883-91.  Back to cited text no. 17
    
18.
Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011;365:981-92.  Back to cited text no. 18
    
19.
Navgren M, Forsblad J, Wieloch M. Bleeding complications related to warfarin treatment: A descriptive register study from the anticoagulation clinic at Helsingborg Hospital. J Thromb Thrombolysis 2014;38:98-104.  Back to cited text no. 19
    
20.
Schulman S, Kearon C, Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 2005;3:692-4.  Back to cited text no. 20
    
21.
Gauger PG, Guinea AI, Reeve TS, Delbridge LW. The spectrum of emergency admissions for thyroidectomy. Am J Emerg Med 1999;17:591-3.  Back to cited text no. 21
    
22.
Onal IK, Dagdelen S, Atmaca A, Karadag O, Adalar N. Hemorrhage into a thyroid nodule as a cause of thyrotoxicosis. Endocr Pract 2006;12:299-301.  Back to cited text no. 22
    
23.
Kasagi K, Hattori H. A case of destructive thyrotoxicosis induced by neck trauma. Thyroid 2008;18:1333-5.  Back to cited text no. 23
    
24.
Mizokami T, Okamura K, Hirata T, Yamasaki K, Sato K, Ikenoue H, et al. Acute spontaneous hemorrhagic degeneration of the thyroid nodule with subacute thyroiditis-like symptoms and laboratory findings. Endocr J 1995;42:683-9.  Back to cited text no. 24
    
25.
Skowsky WR. Toxic hematoma: An unusual and previously undescribed type of thyrotoxicosis. Thyroid 1995;5:129-32.  Back to cited text no. 25
    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1]

This article has been cited by
1 Warfarin
Reactions Weekly. 2015; 1546(1): 200
[Pubmed] | [DOI]



 

Top
Print this article  Email this article
Online since 7th April '04
Published by Wolters Kluwer - Medknow