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|LETTER TO THE EDITOR
|Year : 2016 | Volume
| Issue : 4 | Page : 251-252
Ischemic stroke due to occlusion of the artery of Percheron
Sulena1, Paramdeep Singh2, Rupinderjeet Kaur3, Naveen Kumar4
1 Department of Neurology, Guru Gobind Singh Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, India
2 Department of Radiology, Guru Gobind Singh Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, India
3 Department of Medicine, Guru Gobind Singh Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, India
4 Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
|Date of Web Publication||11-Apr-2016|
Department of Radio Diagnosis, Guru Gobind Singh Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Sulena, Singh P, Kaur R, Kumar N. Ischemic stroke due to occlusion of the artery of Percheron. Indian J Crit Care Med 2016;20:251-2
|How to cite this URL:|
Sulena, Singh P, Kaur R, Kumar N. Ischemic stroke due to occlusion of the artery of Percheron. Indian J Crit Care Med [serial online] 2016 [cited 2018 Jul 21];20:251-2. Available from: http://www.ijccm.org/text.asp?2016/20/4/251/180052
A 60-year-old female presented with acute onset altered sensorium, vertical gaze ophthalmoparesis, side-to-side, and up-and-down 2-4 Hz head tremors that were aggravated on sitting or standing and disappeared on sleeping along with mild memory disturbances. An urgent magnetic resonance imaging (MRI) of the brain demonstrated symmetric bilateral restricted diffusion in paramedian thalami and rostral midbrain on diffusion-weighted MRI [Figure 1] and [Figure 2] showing the "V" sign which was consistent with acute infarcts and compatible with occlusion of the artery of Percheron. Magnetic resonance angiography (MRA) showed patent posterior circulation including the tip of the basilar artery and both posterior cerebral arteries.
|Figure 1: Diffusion-weighted image (a) and corresponding apparent diffusion coefficient map (b) showing V-shaped area of diffusion restriction in midbrain consistent with acute infarcts|
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|Figure 2: Fluid-attenuated inversion recovery-weighted image showing symmetrical hyperintense signal in bilateral paramedian thalami which were also showing diffusion restriction and hence consistent with acute infarction|
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The thalami and midbrain have a complex blood supply with multiple feeding arteries. The medial parts of the thalami are supplied by the perforating thalamic arteries (also named as paramedian arteries), which arise from the posterior circulation. , Percheron delineated four normal variations of the neurovascular anatomy of the thalami and midbrain. In variation II-b, the bilateral perforating thalamic arteries originate from one central artery known as the artery of Percheron, which arises from the P1 segment of one posterior cerebral artery.  This artery is a single trunk that provides bilateral arterial supply to the paramedian thalami and the rostral midbrain. Occlusion of this artery leads to bilateral thalamic and mesencephalic infarctions. These infarcts are typically defined by a triad of altered mental status, vertical gaze palsy, and memory deterioration. However, the clinical diagnosis is difficult in majority of the cases because the complex arterial anatomy causes large clinical variability. , Our patient presented with all the three typical features of this stroke syndrome along with head tremors. The "V" sign on MRI appears as a well-defined pattern of V-shaped hyperintensity on axial fluid-attenuated inversion recovery and/or diffusion-weighted images along the pial surface of the midbrain adjoining the interpeduncular fossa.  Since artery of Percheron is too small to be visualized by computed tomography angiography or MRA, the angiographic studies are frequently normal in these cases. 
To conclude, the artery of Percheron is an uncommon entity which originates from the first segment of the posterior cerebral artery and gives rise to bilateral medial thalamic and midbrain perforators. Our patient had artery of Percheron infarct along head tremors which has not been reported before. The etiology of head tremors might be due to red nucleus involvement.
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[Figure 1], [Figure 2]