Advertisment Polium-B
Indian Journal of Critical Care Medicine
An open access publication of ISCCM™ 
 
Users online: 1663 
     Home | Login 
  About Current Issue Archive Search Instructions Online Submission Subscribe Etcetera Contact  
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed478    
    Printed9    
    Emailed0    
    PDF Downloaded160    
    Comments [Add]    

Recommend this journal

 

 RESEARCH ARTICLE
Year : 2018  |  Volume : 22  |  Issue : 9  |  Page : 629--631

The importance of serial time point quantitative assessment of cardiac Troponin I in the diagnosis of acute myocardial damage


1 Department of Pathology, Choithram Hospital and Research Centre, Indore, Madhya Pradesh, India
2 Department of Cardiology, Choithram Hospital and Research Centre, Indore, Madhya Pradesh, India

Correspondence Address:
Dr. Dhananjay S Chitnis
Department of Pathology, Choithram Hospital and Research Centre, Manikbagh Road, Indore, Madhya Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijccm.IJCCM_8_16

Rights and Permissions

Objective: The present study was aimed to establish a threshold value for cardiac troponin I (cTnI) for nonacute coronary syndrome (ACS) participants from the local population and also to determine the importance of serial time point estimation of cTnI in acute myocardial infarction (AMI), non-ST-elevated MI (NSTEMI), and unstable angina cases. Methods: The present study included 194 cases, admitted in ICCU with the complaint of anginal pain; 31 were diagnosed with AMI with typical electrocardiography (ECG) changes; whereas, 48 cases were diagnosed with NSTEMI. The latter group of cases was selected for the time point study of cTnI release at 0–4 h, 6–12 h, 72 h, and 144 h of admission. cTnI levels were assessed using the Abbott ARCHITECT i1000SR system. Results: ACS was clinically ruled out in 98 cases, and cTnI level for them was used to decide cTnI threshold for the non-ACS group. cTnI level was checked in 17 cases of unstable angina. The threshold value of cTnI for non-ACS participants was 0.1 ng/ml and can be considered as cut-off value for the regional population. The data suggested that the peak of cTnI levels in most of the AMI cases reached during 6–12 h. The cTnI levels were lower than 0.1 ng/ml, and no significant change in ECG was noticed in 17 cases of unstable angina. Conclusion: The present study suggested that the repeat of cTnI assay after 4–6 h of admission is required if the initial value is <3 ng/ml.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 7th April '04
Published by Wolters Kluwer - Medknow