The prevalence of post-traumatic stress disorder symptoms in relatives of severe trauma patients admitted to the intensive care unit
LV Pillai, D Ambike, S Husainy, N Vaidya, SD Kulkarni, S Aigolikar
Department of Critical Care Medicine, Lokmanya Hospitals, Chinchwad, Pune, India
L V Pillai
Department of Critical Care Medicine, Lokmanya Hospitals, Chinchwad, Pune - 411 033
Aim: To study the prevalence of symptoms suggestive of post-traumatic stress disorder in relatives of severe trauma patients admitted to the ICU. Materials and Methods: 177 relatives of trauma patients admitted to the ICU were studied to evaluate the negative psychological impact resulting from this admission by using the impact of event scale-revised [IES-R]. About 76 of these relatives could be followed up again with questionnaire after 2 years. Result: Of the 177 relatives, 85 (48%) were males and 92 (52%) females with no statistically significant difference in their scores. About 7 days after admission, 34-54% of the 177 relatives had moderate and 19-41% had severe symptoms suggestive of PTSD. For the 76 relatives who participated in both 2002 and 2004, symptoms suggestive of PTSD were moderate in 39-61% and severe in 12-39% initially. After 2 years the scores were moderate in 12-14% and severe in 4-5%. Maximum scores amongst the three subscales were for hyperarrousal symptom with mean scores of 2.1±1. In the group-which could be followed up after 2 years, initially 79% of the respondents had sum of IES-R scores ?26 suggesting severe symptoms, which declined to 14% after 2 years. Conclusion: Findings of this study suggest that 79% of the relatives of severe trauma patients develop PTSD symptoms following ICU admission. In most, the scores reduced with time but 14% continued to have severe scores at the end of 2 years suggesting the presence of persisting psychological disturbance in them.
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Pillai L V, Ambike D, Husainy S, Vaidya N, Kulkarni S D, Aigolikar S. The prevalence of post-traumatic stress disorder symptoms in relatives of severe trauma patients admitted to the intensive care unit.Indian J Crit Care Med 2006;10:181-186
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Pillai L V, Ambike D, Husainy S, Vaidya N, Kulkarni S D, Aigolikar S. The prevalence of post-traumatic stress disorder symptoms in relatives of severe trauma patients admitted to the intensive care unit. Indian J Crit Care Med [serial online] 2006 [cited 2015 Apr 28 ];10:181-186
Available from: http://www.ijccm.org/text.asp?2006/10/3/181/27860
The unexpectedness of an accident and the subsequent intensive care admission can be a stressful event for the relatives of trauma victims. Anxiety in the relatives during the hospitalization is understandable but whether it leads to later psychological morbidity has been the focus of many recent studies.,,, Various factors combine to create a psychologically devastating condition in relatives of ICU patients. Major issues are lack of information about the nature of the illness, incessant reminders of the potential complication during consent for investigations, procedures or surgery, financial burden of hospitalization and most importantly restricted access to the patient.
Acute stress disorder is associated with increased risk of post-traumatic stress disorder (PTSD). Diagnosis of PTSD was introduced in the 3rd edition of diagnostic manual of mental disorder (DSM). It is a severe condition characterized by persistent re-experiencing of the event, avoidance of event-related stimuli and symptoms of increased arousal. According to DSM-1V, the traumatic event criterion includes two component criteria. Criterion 1A stipulates, 'The person experienced, witnessed or has been confronted with an event or events that involved actual or threatened death or serious injury or a threat to the physical integrity of self or others'. While criterion 2 stipulates 'the person's response involved intense fear, helplessness or horror'. As per this definition, we felt that the next of kin of trauma victims fulfilled both the criterion and therefore were at risk for developing symptoms suggestive of PTSD. Even though both physical and emotional threats are implied in the criterion, earlier research focused on physical threat criteria of severe trauma. In this paper it is proposed to study the emotional threat, i.e. the effect of trauma ICU admission on relatives (next of kin) and to decide if there was a negative psychological sequel following trauma ICU admission by using the Horowitz's Impact of Event -Revised Scale (IES-R). Although IES-R is not meant to be a proxy for the diagnosis of PTSD, it has been used frequently both in trauma and nontrauma related studies alone or along with other scales of psychiatric illness.,,,,
Materials and Methods
Relatives (spouse, parent or sibling who were identified as next of kin) of patients who were admitted in the ICU (July-Dec. 2002), as a result of severe trauma and consented to answer the questions participated in the study. They were all above 18 years of age and literate. The patients had similar severe injuries (polytrauma or head injuries with GCS >8) requiring ICU stay of Statistical analysis
All values are reported as mean and SD for normally distributed variables. Data are presented in actual numbers and percentages. If a difference was found, a paired t -test was used to compare groups at each time point. Correlations between variables were calculated by the Pearson correlation coefficient. A P value SPSS 12.0 software.
IES-R is a standardized measure of PTSD symptoms. It is a 22-items scale, which taps into intrusion, avoidance and hyperarrousal symptoms. Respondents are instructed to rate on a 5 point Likert scale from 0 (not at all) to 4 (extremely) how affected they felt by the traumatic event during the preceding 7 days. As the event 'accident' was a specific event occurring suddenly at a specific time it was considered as an appropriate event for administration of IES-R scale. There was no modification in the wording order or content when translating into the language of the respondent and was administered by a clinical psychologist.
Subsequently both the mean score in each group, i.e., intrusion avoidance and hyperarrousal symptoms along with the standard deviation (SD) as well as the sum of the scores were considered while analyzing the data. Sum of the score P = 0.7558). Of the respondents 22% were graduates 20% were school dropouts and 58% had school level education, i.e. majority had at least school level education. Abour 60% belonged to middle income group earning between Rs. 5000-10000. None were below poverty line.
After 2 years later 80 (45%) of the original respondents could be traced. About 76 (43%) responded to the telephonic interview. About four were abusive and refused to answer saying all this was a gimmick. Rest (97) could not be traced due to change in address, telephone numbers or had no telephones. Eleven of the patients had died during this interval. One relative was extremely thankful to be able to speak because she had been feeling very depressed and had many guilt feelings.
The mean IES-R scores on Intrusion, Arousal and Hyperarrousal subscales for all 177 respondents are as shown in [Table 1]. The correlation between avoidance and intrusion subscale was 0.54. [Table 2] compares the mean IES-R scores of the same group of respondents in 2002 and 2004.
Analysis of the initial data of 177 respondents in 2002, suggests that symptoms of PTSD were moderate in 34-54% and severe in 19-41% of the respondent's ([Table 1] lowest and highest scores). In the 76 cases who responded both in 2002 and 2004, symptoms suggestive of PTSD were moderate in 39-61% and severe in 12-39% initially [Table 2] but showed significant reduction at the end of 2 years. The symptoms were now moderate in 12-14% and severe in 4-5% [Table 2]. [Table 3] and [Figure 1] show reduction in the mean subscales over time in this group.
As indicated in [Table 4], if the sum of the subscales is considered, it is seen that only 3% had normal scores while 79% had scores suggestive of severe psychological distress seven days after the ICU admission of their relative. About 76% of the 76 relatives in 2002 who could be followed up for 2 years had sum of the scores £26 suggesting severe stress, although normalization of symptoms in 47% of them occurred by the end of 2 years [Table 5]. These data also show that at the end of 2 years 38 and 14% continued to have moderate and severe scores, respectively.
It is accepted that relatives of ICU patients will be under severe stress as long as their patients are critically ill but whether this stress predisposes them to chronic psychological illness is a cause for concern. It has been observed that the intensity of psychological response of an individual to a psychologically traumatic experience is associated with a degree of controllability, predictability, perceived threat, the relatives success or attempts to minimize injury to oneself or others and the actual loss. Our study focused on trauma ICU admissions because all these stressors were present in relatives of trauma victims. Relatives had little choice of hospital or doctors as patients were usually directly brought to the hospital by bystanders and were often too sick to be transferred. There were mounting bills, uncertainty of an outcome with initial mortality due to trauma and subsequent mortality and morbidity due to infections. Multi-disciplinary involvement confused relatives about the identity of the treating doctors. There was either too much information or too little and often in language and anatomical terms the relatives found it difficult to comprehend. And above all there was restricted access to the patient.
We believe ours is the first prospective Indian study of its kind and one of the earliest in critical care to focus attention on relatives of ICU patients. It is also one with the longest follow-up of 2 years. The extreme stress and consequent post-traumatic stress disorder in ICU patient's relatives have recently been well-documented.,,,, Pochard's group in a prospective multi-centred study of 78 French ICUs reported more than two thirds of family members visiting intensive care unit patients as having symptoms of anxiety or depression during the first days of the hospitalization irrespective of whether the patient was well enough to be discharged or near death. We had similar result in our study with two third of the relatives showing high IESR score in the early days of ICU admission, which persisted in a considerable number of patients even at the end of 2 years.
We used the IES-R to evaluate for PTSD symptoms. The IES-R was designed and validated using a specific time frame of the past 7 days. We have used the same time frame of 7 days for our initial assessment, thus our data are comparable with those collected with this standard time frame. IES-R scores the impact of an event on an individual and gives an assessment of the symptomatic status with respect to the three domains of PTSD symptoms- avoidance, intrusion and hyper arousal occurring as a result of exposure to a traumatic stressor. Similar studies of relatives of ICU patients have used the same scale for diagnosing risk for PTSD., A meta-analysis of various studies using IES-R has concluded that cultural differences were relatively insignificant in the development of PTSD as measured by IES-R hence its use was applicable in our patient population Men and women appeared equally stressed in our study with no statistically significant differences in their scores. Incidence of PTSD appears to be similar in males and females although Elie Azoulay group have reported a higher incidence in females.
When Horowitz, Wilner, Alvarez's cutoff point (IES total >26) was used as measure of symptom severity more than two thirds [Table 4] of the relatives showed symptoms of traumatic stress reaction within first week of ICU admission in our study. In Elie Azoulay study a score of 30 was a cause for concern, while Christina Jones group considered a score of 19 to suggest significant risk for PTSD. Different cut off points are likely to create confusion when studies are compared and success of remedial measures assessed.
Weiss recommended using mean score and anchor points score rather than the sum. Here again the mean values in each subscale indicated that more than two third of trauma relatives had symptoms suggestive of PTSD [Table 1]. The correlation between Avoidance and Intrusion subscale was 0.54 in the 177 cases indicating that the subscale were relatively independent of one another, each of them representing a different type of reaction due to stressful event. As in all other reports of PTSD, hyper arousal symptoms were the most common severe psychological disturbance. This is in accordance with the inclusion criteria in the diagnosis of PTSD.
These data, when analyzed either way using IES-R cut-off or mean value, show that more than two third relatives were at risk of PTSD in the initial days with a high incidence of persistence of symptoms in moderate to severe grade in about 50% of the relatives at the end of 2 years. Of these, 14% had scores above 26 suggesting very high possibility of PTSD. Can this persistence of symptoms at the end of 2 years be another psychological burden of injury? As in Horowitz postulate, intrusion and avoidant symptoms became less frequent with time in our study also. Mean scores on the three subscales (intrusion, avoidance, hyperarrousal) measured after 2 years show a clear shift from severe scale to moderate and mild levels suggesting its linear relation with time, the passage of time reducing the severity of stress in the same group of individuals. About 79% of the relatives in the present study showed a traumatic stress reaction, which declined significantly ( P on end of life issues will provide guidance to critical care practitioners, but one will have to keep in mind the results of Elie Azoulay study, which concluded that a relative's participation in end of life issues is an independent risk factor for subsequent development of PTSD symptoms.
With relatives having to take major decisions in all critically ill patients, focus is moving from patient centeredness to family centeredness. Critical care family assistance programs have been developed with a goal to respond to the unmet needs of the families, focusing on five categories of family need: information, comfort, support, assurance and anxiety alleviation and need for proximity and accessibility.,, Recent research links inadequate information, information too difficult to understand or when given in insufficient time with high risk for development of PTSD among family members of ICU patients.
Our study was limited to a single center and to relatives of trauma patients only and other scales such as hospital anxiety and depression were not studied relatives needs in our ICU's are also the same. Improvements in communication skills, a waiting area, counseling rooms and compassionate care by the ICU staff are simple measures to reduce stress in the relatives.
The treatment of trauma patient should not end with the treatment of the patient alone. The relatives are also subjected to the emotional stress, which could cause lasting psychological scars. Our study shows that two third of the trauma ICU relatives are at high risk to develop PTSD, with fourteen percent of them showing residual psychological disorder even after 2 years. Research is needed to devise preventive and early-detection strategies for PTSD especially in those who share in end-of-life decisions. Measures such as hospital anxiety and depression scales and hospital satisfaction scales may predict which of these relatives have more possibility of developing PTSD.
Future studies also should examine the relationship between relatives with high PTSD scores and their satisfaction with the quality of treatment in ICU. Another area of study would be its impact on the outcome of patients in terms of recovery both physical and emotional, of the patients in their care.
Although all of us have little choice over the given rules, we need not turn them into fences. Simple measures such as a grieving and counseling room, a waiting area with basic amenities can provide comfort to the relatives. Guidelines for consents for procedure, information of seriousness will need to be developed which will reduce the number of consent forms the patient's relatives may have to sign. Above all there is a need for adequate training to doctors on communication with relatives of patients. There is space, time and scope for creativity, compassion and modification in the existing situations so as to reduce stresses to the relatives.
We would like to thank Ms. Sarita Kamble M.Sc, Mr. Manohar Patil M.Sc. for their statistical help.
|1||Azoulay E, Pochard F, Kentish-Barnes N, Chevret S, Aboab J, Adrie C, et al . Risk of post-traumatic stress symptoms in family members of intensive care unit patients. Am J Respir Crit Care Med 2005;171:987-94.|
|2||Jones C, Skirrow P, Griffiths RD, Humphris G, Ingleby S, Eddleston J, et al . Post-traumatic stress disorder-related symptoms in relatives of patients following intensive care . Intensive Care Med 2004;30:456-60. |
|3||Jones C, Skirrow P, Griffiths RD, Humphris G, Dawson S, Eddleston J, et al . Predicting intensive care relatives at risk of post traumatic stress disorder. Br J Anaesthesia 2000;84:666-7.|
|4||Pochard F, Darmon M, Fassier T, Bollaert PE, Cheval C, Coloigner M, et al . French FAMIREA study group. Symptoms of anxiety and depression in family members of intensive care unit patients before discharge or death. A prospective multicenter study. J Crit Care 2005;20:90-6.|
|5||Harvey AG, Bryant RA. The relationship between acute stress disorder and post-traumatic stress disorder: A prospective evaluation of motor vehicle accident survivors. J Consult Clin Psychol 1998;66:507-12.|
|6||American Psychiatric Association. Diagnostic and statistical manual of mental disorders (4th), Washington, DC: 1994.|
|7||Weiss DS, Marmar CR. The impact of events scale-revised, in assessing psychological trauma and PTSD: A practitioners' handbook. edited by Wilson JP, Keane TM. Guilford: New York; 1997.|
|8||Mason S, Wardrope J, Turpin G, Rowlands A. The psychological burden of injury: An 18 month prospective cohort study. Emerg Med J 2002;19:400-4.|
|9||Horowitz MJ, Wilner N, Alvarez W. Impact of event scale: A measure of subjective stress. Psychosomat Med 1979;41: 209-18. |
|10|| Sundin EC, Horowitz MJ. Horowitz's impact of event scale evaluation of 20 years of use. Psychosom Med 2003;65:870-6.|
|11||Yehuda R. Post-traumatic stress disorder. N Engl J Med 2002;346:108-14.|
|12||Sessler CN. Caring for those who car the critical care family assistance program. Chest 2005;128:1101-3.|
|13||Azoulay E, Pochard F, Chevret S, Adrie C, Annane D, Bleichner G, et al. Half the family members of intensive care unit patients do not want to share in the decision-making process: A study in 78 French intensive care units. Crit Care Med Sept 2004;32:1832-8.|
|14||Mani RK, Amin P, Chawla R. Limiting life-prolonging interventions and providing palliative care towards the end-of-life in Indian intensive care units ISCCM's position statement. Indian J Crit Care Med 2003;9:96-105.|
|15||Guntupalli K, McCaffree DR, Vender J, Clary G, Locicero J 3rd. Project director's perspective -The critical care family assistance program. Chest 2005;128:106S-10S.|
|16||Herridge MS, Angus DC. Acute lung injury: Affecting many lives. N Engl J Med 2005;353:1736-8.|
|17||Dowling J, Vender J, Guilianelli S, Wang B. A model of family-entered care and satisfaction predictors. The critical care family assistance program. Chest 2005;128:81S-92S.|