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Year : 2017  |  Volume : 21  |  Issue : 3  |  Page : 122-126  

Blood glucose variability and outcomes in critically ill children

Kirti Mahadeorao Naranje1, Banani Poddar2, Arpita Bhriguvanshi1, Richa Lal3, Afzal Azim2, Ratender K Singh2, Mohan Gurjar2, Arvind K Baronia2 
1 Department of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
3 Department of Paediatric Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
Banani Poddar
Department of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow  -  226  014, Uttar Pradesh
India

Objectives: To find the incidence of hyperglycemia (blood glucose [BG] ≥150 mg/dl), hypoglycemia (BG ≤60 mg/dl), and variability (presence of hypoglycemia and hyperglycemia) in critically ill children in the 1st week of Intensive Care Unit (ICU) stay and their association with mortality, length of ICU stay, and organ dysfunction. Materials and Methods: The design was a retrospective observational cohort study. Consecutive children ≤18 years of age admitted from March 2003 to April 2012 in a combined adult and pediatric closed ICU. Relevant data were collected from chart review and hospital database. Results: Out of 258 patients included, isolated hyperglycemia was seen in 139 (53.9%) and was unrelated to mortality and morbidity. Isolated variability in BG was noted in 76 (29.5%) patients and hypoglycemia was seen in 9 (3.5%) patients. BG variability was independently associated with multiorgan dysfunction syndrome on multivariate analysis (adjusted odds ratio [OR]: 7.1; 95% confidence interval [CI]: 1.6–31.1). Those with BG variability had longer ICU stay (11 days vs. 4 days, on log-rank test, P = 0.001). Insulin use was associated with the occurrence of variability (adjusted OR: 3.6; 95% CI: 1.8–7.0). Conclusion: Glucose disorders were frequently observed in critically ill children. BG variability was associated with multiorgan dysfunction and increased ICU stay.


How to cite this article:
Naranje KM, Poddar B, Bhriguvanshi A, Lal R, Azim A, Singh RK, Gurjar M, Baronia AK. Blood glucose variability and outcomes in critically ill children.Indian J Crit Care Med 2017;21:122-126


How to cite this URL:
Naranje KM, Poddar B, Bhriguvanshi A, Lal R, Azim A, Singh RK, Gurjar M, Baronia AK. Blood glucose variability and outcomes in critically ill children. Indian J Crit Care Med [serial online] 2017 [cited 2017 Jul 26 ];21:122-126
Available from: http://www.ijccm.org/article.asp?issn=0972-5229;year=2017;volume=21;issue=3;spage=122;epage=126;aulast=Naranje;type=0