Indian Journal of Critical Care Medicine
Volume 26 | Issue 5 | Year 2022

Dengue and HELLP: Beware of the Masquerade

Rohit Patnaik1, Shruthi Kulkarni2, Nupur Karan3

1Department of Critical Care Medicine, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India

2Department of General Medicine, St Johns Medical College, Bengaluru, Karnataka, India

3Department of Anaesthesiology, MPMMCC, Varanasi, Uttar Pradesh, India

Corresponding Author: Rohit Patnaik, Department of Critical Care Medicine, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India, Phone: +91 9833116430, e-mail:

How to cite this article: Patnaik R, Kulkarni S, Karan N. Dengue and HELLP: Beware of the Masquerade. Indian J Crit Care Med 2022;26(5):639–640.

Source of support: Nil

Conflict of interest: None


HELLP is a syndrome characterized by hemolysis, elevated liver enzymes, and low platelets. It is a rare complication of pregnancy and is usually associated with pre-eclampsia. However, 10–20% cases of HELLP can present without hypertension. Dengue fever is an arboviral-borne tropical illness that is characterized with fever, thrombocytopenia, and bleeding manifestations. We present a case of a primigravida with HELLP syndrome masquerading in the background of dengue fever. Unique features to this case report include delayed presentation of HELLP syndrome with normotension which can have overlapping features with dengue fever, especially in term pregnancy. This case highlights the need of strict vigilance in cases of dengue fever with pregnancy.

Keywords: Cesarean section, Dengue fever, Fetomaternal outcome, HELLP syndrome, Obstetric ICU.


HELLP and dengue can have similar presentation making the primary diagnosis difficult. Such cases are uncommon. This report elaborates on such a case.


HELLP is a unique syndrome characterized by hemolysis, elevated liver enzymes, and low platelet count. All three components are required for the diagnosis. The incidence of HELLP is less than 1% of all pregnancies. Partial HELLP syndrome is a condition when any one element is missing. A probable case of dengue fever (DF) is an acute febrile illness with two or more of the characteristic manifestations.1 Both conditions can present with severe thrombocytopenia and deranged liver function tests.2 We present an interesting case of HELLP syndrome masquerading in the background of DF. Hence it is important to clearly establish the diagnosis as treatment for both conditions is different.


A 19-year-old primigravida at 36 weeks gestation was presented with history of headache and fever for 3 days, without associated chills and rigor. She underwent regular antenatal checkup. On presentation she was febrile, conscious, and well-built with normal hemodynamic parameters. Detailed examination revealed bilateral pedal edema. Her lab investigations are illustrated in Table 1.

Table 1: Lab investigations over time of the patient
  Day 1 Day 6 Day 8 (Postoperative day 1) Reference range
Hemoglobin (gm/dL) 11.8 13.3 10.0 13.0–17.0
Total WBC counts (per mm3) 4,900 3,519 2,480 4,000–10,000
Platelet counts (per mm3) 6,000 19,000 42,000 150–400
Total bilirubin (mg/dL) 0.98 1.9 0.86 0.3–1.2
Direct bilirubin (mg/dL) 0.77 1.29 0.62 <0.3
AST (IU/L) 488 345 69 <50
ALT (IU/L) 242 292 134 <50
aPTT (seconds) 40.5 25.4 20.6 15–30
IPF (%) 19.1 1–6
LDH (U/L) 1,345 2,560 1,252 100–190

Relevant biochemistry workup and thyroid function test were normal. Rapid HIV and HbsAg immunoassay were negative. Dengue NS1 and IgM ELISA were reactive. Immature platelet fraction was 19.1% and vitamin B12 levels were 180 ng/mL. Urine microscopy showed albumin 2+ with 1 RBC/HPF. Peripheral smear showed normocytic normochromic blood picture with occasional schistocytes. Blood cultures were sterile. She was treated with adequate hydration and all supportive measures for her DF. Vitamin B12 supplementation and 4 units of RDP transfusion were given for persisting low platelet counts. However, despite 6 days of treatment, there was no improvement in platelet counts, although fever had subsided. Repeat LFT and peripheral smear on day 6 showed worsening transaminitis, rising LDH levels and increase in schistocytes. She was also noted to have high BP in increasing trend from day 6 for which she was started on antihypertensives. Intravenous dexamethasone 4 mg once daily was started for possible benefit of improving platelet counts with suspected HELLP. On day 7, she had an episode of generalized tonic-clonic seizure. Intravenous lorazepam and magnesium sulfate were given. Blood sugars were 90 mg/dL and BP was 190/90 mm Hg at the time of seizure. Postictal confusion persisted for 30 minutes and she was shifted to intensive care unit (ICU) for further management. CT brain was normal. She underwent emergency cesarean section and delivered a healthy 2.54 kg female child. She was transfused with 2 units of packed cells and 4 units of random-donor-platelets intraoperatively. Postoperatively she had improving platelet counts and decreasing transaminitis and LDH level. There was no further drop in hemoglobin and platelet counts. Her blood pressure normalized on day 3 postoperatively. Repeat cultures in ICU stay were also sterile. She was discharged on day 16 from admission, with normal blood investigations.


The 2009 Revised Case definitions by WHO for dengue includes probable or laboratory-confirmed DF. DF consists of following phases:

This patient presented to us at the end of febrile phase with severe thrombocytopenia, without features of systemic vascular leak or hemorrhage and positive NS1 antigen test. Thus, she was managed as laboratory confirmed DF without warning signs.3 Prophylactic platelet transfusion was also given to our patient as her platelet counts were below 10,000 cells/mm3.1 A confirmed NS1 antigen positivity with mild albuminuria, transaminitis, and normal BP did not raise suspicion of other differential diagnosis. However, she had persisting thrombocytopenia even after day 7 of illness. Although delayed recovery of thrombocytopenia has been documented in several cases of dengue fever, it is still rare, especially with DF without warning signs.4

According to Tennessee classification, following parameters should be present for diagnosing HELLP:

Our patient satisfied all criteria of complete HELLP syndrome only on day 6. Incidentally, normotension and mild proteinuria were also present. Hypertension and proteinuria are known to be absent in 10–20% of HELLP.5 Based on ACOG recommendation on the possible benefit of corticosteroids, intravenous dexamethasone 4 mg once daily was given.6,7 The presence of seizure episode and dramatic improvement in platelets counts post-delivery suggests the presence of an underlying HELLP syndrome which was missed due to the presence of concomitant thrombocytopenia of DF.7

Till date, only one such case report has been documented.8 In that case, patient had gross proteinuria on urine microscopy, underwent normal vaginal delivery within 6 hours of admission, and had intraoperative seizures. However, in our case, patient came with features suggestive of only DF with mild proteinuria. When her platelet counts did not improve along with worsening of liver functions, a diagnosis of masquerading HELLP was thought. It is possible that presenting normotension was due to the combined effect of HELLP and DF. We also cannot deny that our patient might be a case of normotensive HELLP. DF and HELLP have overlapping features and differentiating between them in normotensive patients is difficult. Ignoring the possibility of HELLP in such cases leads to delayed treatment and threat to patient’s life.


HELLP and dengue have congruent features. This case reiterates the fact that HELLP can be easily missed in cases of DF in pregnancy, especially in cases presenting near term pregnancy.


Rohit Patnaik

Shruthi Kulkarni

Nupur Karan


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3. Shastri PS, Taneja S. Dengue and other viral hemorrhagic fevers. Indian J Crit Care Med 2021;25(Suppl 2):S130–S133. DOI: 10.5005/jp-journals-10071-23814.

4. Verma SP, Hamide A, Wadhwa J, Sivamani K. Corticosteroid responsive prolonged thrombocytopenia in a case of dengue fever. BMJ Case Rep 2013;2013:200249. DOI: 10.1136/bcr-2013-200249.

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6. ACOG Practice Bulletin No. 202: gestational hypertension and preeclampsia. Obstet Gynecol 2019;133(1):e1–e25. DOI: 10.1097/AOG.0000000000003018.

7. Ditisheim A, Sibai BM. Diagnosis and management of HELLP syndrome complicated by liver hematoma. Clin Obstet Gynecol 2017;60(1):190–197. DOI: 10.1097/GRF.0000000000000253.

8. Manappallil RG, Surendran S, Kumar A, Prasad G. Normotensive HELLP syndrome in the midst of Dengue fever. Asian J Med Sci 2018;9(2):40–42. DOI: 10.3126/ajms.v9i2.18764.

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