Indian Journal of Critical Care Medicine
Volume 26 | Issue 4 | Year 2022

MIS-A after COVID-19: Points to Ponder

Pranav Ish1https://orcid.org/0000-0003-1701-4970, Shekhar Kunal2https://orcid.org/0000-0002-0319-9241, Pirabu Sakthivel3https://orcid.org/0000-0002-6941-9892

1Department of Pulmonary Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, New Delhi, India

2Department of Cardiology, ESI Medical College and Hospital, Faridabad, Haryana, India

3Department of ENT and Head-Neck Surgery, Maulana Azad Medical College, New Delhi, India

Corresponding Author: Pranav Ish, Department of Pulmonary Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, New Delhi, India, Phone: +91 9958356000, e-mail: pranavish2512@gmail.com

How to cite this article: Ish P, Kunal S, Sakthivel P. MIS-A after COVID-19: Points to Ponder. Indian J Crit Care Med 2022;26(4):533.

Source of support: Nil

Conflict of interest: None

Keywords: Coronavirus disease-2019 (COVID-19), COVID-19 infection, Multiple organ failure.


We read with interest the article by Arjun et al.1 and congratulate the authors for the work-up of the patients and attempt to diagnose and treat MIS-A which often is underdiagnosed and ignored.2 However, there are a few points to ponder in this case series.


Pranav Ish https://orcid.org/0000-0003-1701-4970

Shekhar Kunal https://orcid.org/0000-0002-0319-9241

Pirabu Sakthivel https://orcid.org/0000-0002-6941-9892


1. Arjun R, Niyas VKM, Thomas SM, Raman M, Thomas A, Aloysius W, et al. Multisystem inflammatory syndrome in adults and adolescents (MIS-A) associated with COVID-19 infection: a single-center experience. Indian J Crit Care Med 2022;26(1):145–148. DOI: 10.5005/jp-journals-10071-24066.

2. Iyengar KP, Nune A, Ish P, Botchu R, Shashidhara MK, Jain VK. Multisystem inflammatory syndrome after SARS-CoV-2 vaccination (MIS-V), to interpret with caution. Postgrad Med J 2021:postgradmedj-2021-140869. DOI: 10.1136/postgradmedj-2021-140869.

3. Vogel TP, Top KA, Karatzios C, Hilmers DC, Tapia LI, Moceri P, et al. Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine 2021;39(22):3037–3049. DOI: 10.1016/j.vaccine.2021.01.054.

4. Davogustto GE, Clark DE, Hardison E, Yanis AH, Lowery BD, Halasa NB, et al. Characteristics associated with multisystem inflammatory syndrome among adults with SARS-CoV-2 infection. JAMA Netw Open 2021;4(5):e2110323. DOI: 10.1001/jamanetworkopen.2021.10323.

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