Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 10 , ISSUE 1 ( January, 2006 ) > List of Articles

CASE REPORT

Transfusion-associated graft-versus-host disease in an immunocompetent individual

Surekha Devi Allanki, Shailesh R. Singi, Ramana Dandamudi

Keywords : Irradiation, related donor, TA-GVHD.

Citation Information : Allanki SD, Singi SR, Dandamudi R. Transfusion-associated graft-versus-host disease in an immunocompetent individual. Indian J Crit Care Med 2006; 10 (1):47-49.

DOI: 10.4103/0972-5229.24691

License: CC BY-ND 3.0

Published Online: 00-01-2006

Copyright Statement:  Copyright © 2006; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

A 9 months old immunocompetent male baby was admitted with high grade fever, erythematous maculo-papular rash and frequent loose stools. He was unwell three weeks prior, with febrile illness and anemia, for which he was transfused 2 units of non irradiated whole blood from first-degree family donors (father and mother), in a private hospital. Seven days after transfusion, he became symptomatic. Investigations revealed elevated liver enzymes, elevated bilirubin levels and progressive pancytopenia. Clinical findings and results of skin biopsy and bone marrow examination were consistent with transfusion-associated graft-versus-host disease. He was treated with steroids, Cyclosporin, broad spectrum antibiotics and supported by irradiated blood components. He died on day 10, post admission and day 31, post transfusion, despite intensive medical care.


PDF Share
  1. Sohi I, Jacob S. Transfusion associated GVHD. Indian J Pediatr 2005;72:533-5.
  2. Anju G, Deepak B, Rashna D, Ashim D. Transfusion associated graft versus host disease. Indian Pediatrics 2004;41:1260-4.
  3. Brecher ME, et al. Technical Manual, 14th ed. AABB: Bethesda, MD; 2003. p. 606-7.
  4. Rossi EC, Simon TL, Moss GS, Gould SA. Principles of Transfusion medicine, 2nd ed. Williams & Wilkins: Baltimore; 1996. p. 785-98.
  5. Serefhanoglu K, Turan H, Saba T, Ozer I, Tosun E, Arslan H. Transfusion associated graft-versus-host disease in an immunocompetent individual following cardiac surgery. J Nat Med Assoc 2005;97:418-20.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.