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VOLUME 13 , ISSUE 1 ( March, 2009 ) > List of Articles

CASE REPORT

Severe myocardial depression in a patient with aluminium phosphide poisoning: A clinical, electrocardiographical and histopathological correlation

Viral Shah, Seema Baxi, Tanmay Vyas

Keywords : Aluminium phosphide, myocardial depression, myocyte vacuolation, myocytolysis, phosphide poisoning

Citation Information : Shah V, Baxi S, Vyas T. Severe myocardial depression in a patient with aluminium phosphide poisoning: A clinical, electrocardiographical and histopathological correlation. Indian J Crit Care Med 2009; 13 (1):41-43.

DOI: 10.4103/0972-5229.53117

License: CC BY-ND 3.0

Published Online: 01-04-2012

Copyright Statement:  Copyright © 2009; The Author(s).


Abstract

Aluminium phosphide poisoning is very common in India. It is one of the most fatal poisons. The clinical spectrum of poisoning varies depending upon the dosage and duration of consumption. The main effect of the poison is due to the release of phosphine which inhibits cytochrome oxidase and thereby hampers cellular oxygen utilization. Almost any organ can be affected by aluminium phosphide poisoning. We report a case where the heart was the predominantly affected organ. We describe the clinical symptoms and signs and their correlation with electrocardiographic and histopathological examinations.


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  1. Incidence and outcome of aluminium phosphide poisoning in a hospital study. Indian J Med Res 1991;94:232-5.
  2. Acute aluminium phosphide poisoning-an epidemiological clinical and histopathlogical study. J Assoc Phys India 1989;36:594-6.
  3. Changing trends in acute poisoning in Chandigarh zone: A 25-year autopsy experience from a tertiary care hospital in northern India. Am J Forensic Med Pathol 1999;20:203-10.
  4. Aluminium phosphide poisoning. Emerg Med J 2006;23:e3.
  5. The effect of phosphine on electron transport of mitochondria. Pesticide Biochem Physiol 1976;6:65-84.
  6. Spot diagnosis of aluminium phosphide ingestion: An application of a simple test. J Assoc Phys India 1989;37:219-20.
  7. Aluminium phosphide poisoning: A clinico-pathologic study. J Toxicol Clin Toxicol 1996;34:703-6.
  8. Successful treatment of acute aluminium phosphide poisoning: Possible benefit of coconut oil. Hum Exp Toxicol 2005;24:215-8.
  9. Fat and oil inhibit phosphine release from aluminium phosphide-its clinical implication. Indian J Exp Biol 1994;32:647-9.
  10. Hypomagnesemic atrial fibrillation in a case of aluminium phosphide poisoning. J Assoc Physic India 1989;37:548-9.
  11. Electrocardiographic changes in Quickphos poisoning. Indian Heart J 1985;37:193-5.
  12. Significance of heart rate response in shock due to aluminium phosphide poisoning. J Assoc Phys India 1989;37:708-9.
  13. Electrocardiaograohic changes in aluminium phosphide poisoning. J Assoc Phys India 1985;33:406-9.
  14. Serum and tissue magnesium content in patients of aluminium phosphide poisoning and critical evaluation of high dose magnesium sulphate therapy in reducing mortality. J Assoc Phys India 1994;42:670.
  15. Clinical pharmacology of aluminium phosphide poisoning. Indian J Pharmacol 1992;24:134-7.
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