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VOLUME 15 , ISSUE 1 ( January, 2011 ) > List of Articles

CASE REPORT

Anaphylactic reaction to intravenous diclofenac

Deepak Bansal, Ranju Singh, Neha Baduni, Homay Vajifdar

Keywords : Anaphylaxis, diclofenac sodium, intravenous, pulmonary embolism

Citation Information : Bansal D, Singh R, Baduni N, Vajifdar H. Anaphylactic reaction to intravenous diclofenac. Indian J Crit Care Med 2011; 15 (1):37-39.

DOI: 10.4103/0972-5229.78222

License: CC BY-ND 3.0

Published Online: 00-01-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used as an opioid sparing agent for postoperative analgesia. Anaphylaxis due to intravenous diclofenac sodium is very rare. We report a case of anaphylactic reaction to IV diclofenac sodium, occurring postoperatively in a 25-year-old primigravida, the clinical features of which mimicked pulmonary embolism. The rarity, clinical importance and the diagnostic dilemma associated prompted us to report this case.


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  1. Sen I, Mitra S, Gombar KK. Fatal anaphylactic reaction to oral diclofenac sodium. Can J Anaesth 2001;48:421.
  2. Schabitz WR, Berger C, Knauth M, Meinck HM, Steiner T. Hypoxic brain damage after intramuscular self-injection of diclofenac for acute back pain. Eur J Anaesthesiol 2001;18:763-5.
  3. Hadar A, Holcberg G, Mazor M. Anaphylactic shock after diclofenac sodium (Voltaren). Harefuah 2000;138:211-2.
  4. O′Brien WM. Adverse reactions to non steroidal anti inflammatory drugs: Diclofenac compared with other non-steroidal anti-inflammatory drugs. Am J Med 1986;80:70-80.
  5. Catalano MA. Worldwide safety experience with diclofenac. Am J Med 1986;80:81-6.
  6. Foucher P, Biour M, Blayac JP, Godard P, Sgro C, Kuhn M, et al. Drugs that may injure the respiratory system. Eur Respir J 1997;10:265-79.
  7. Wasserman S. The heart in anaphylaxis. J Allergy Clin Immunol 1986;77:663-6.
  8. Schwartz LB, Metcalfe DD, Miller JS, Earl H, Sullivan T. Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. N Engl J Med 1987;316:1622-6.
  9. Toh KW, Deacock SJ, Fawcett WJ. Severe anaphylactic reaction to cistacurium. Anesth Analg 1999;88:462-4.
  10. van der Linden PW, Hack CE, Struyvenberg A, Roem D, Brouwer MC, de Boer JP, et al. Controlled insect-sting challenge in 55 patients: Correlation between activation of plasminogen and the development of anaphylactic shock. Blood 1993;82:1740-8.
  11. Suzuki J, Shiota S, Hori S, Nakatani Y, Sakamoto M, Aoki S, et al. A case of diclofenac (Voltaren) induced interstitial pneumonitis. Jpn J Chest Dis 2001;60:84-91.
  12. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberst EA. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45.
  13. Ellis AK, Day JH. The role of epinephrine in the treatment of anaphylaxis. Curr Allergy Asthma Rep 2003;3:11-4.
  14. Smith SB, Geske JB, Maguire JM, Zane NA, Carter RE, Morgenthaler TI. Early anticoagulation is associated with reduced mortality for acute pulmonary embolism. Chest 2010;137:1382-90.
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