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VOLUME 15 , ISSUE 1 ( January, 2011 ) > List of Articles


Drug interaction leading to prolonged sedation in a postoperative high risk coronary bypass surgery patient

Shrikant Bobade, Vinay Kulkarni, Sudhir Dhumne, Saurabh Barde, Jitesh Chauhan

Keywords : Erythromycin, midazolam, prolonged sedation

Citation Information : Bobade S, Kulkarni V, Dhumne S, Barde S, Chauhan J. Drug interaction leading to prolonged sedation in a postoperative high risk coronary bypass surgery patient. Indian J Crit Care Med 2011; 15 (1):55-57.

DOI: 10.4103/0972-5229.78230

License: CC BY-ND 3.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2011; The Author(s).


Use of midazolam infusion in mechanically ventilated patient is an established practice in critical care. In our case, the use of erythromycin as a prokinetic agent for better tolerance of enteral feeding and paralytic ileus led to an interaction between midazolam and erythromycin, which resulted in prolonged and deeply sedated patient. In a critically ill patient, there is always a possibility of multiple drug interactions. It is important to understand them and they should be considered before starting new medication.

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