Primary immune deficiency in the intensive care unit: It is never too late to diagnose and treat
Rucha S. Dagaonkar, Tiyas Sen, Zarir F. Udwadia, Mukesh B. Desai
Adult primary immune deficiency, common variable immune deficiency, intravenous immunoglobulin, late onset common immunodeficiency, non-resolving pneumonia
Citation Information :
Dagaonkar RS, Sen T, Udwadia ZF, Desai MB. Primary immune deficiency in the intensive care unit: It is never too late to diagnose and treat. Indian J Crit Care Med 2011; 15 (3):179-181.
Common variable immunodeficiency disorders (CVIDs), a heterogeneous group of primary immune deficiencies, can present at all age. Our patient with a hitherto undiagnosed CVID, symptomatic since middle ages, presented with severe pneumonia. Specific management of his CVID in addition to standard therapy was life-saving.
Geha RS, Notarangelo LD, Casanova JL, Chapel H, Conley ME, Fischer A, et al. Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol 2007;120:776-94.
Bergbreiter A, Salzer U. Common variable immunodeficiency: A multifaceted and puzzling disorder. Expert Rev Clin Immunol 2009;5:167-80.
Aghamohammadi A, Pouladi N, Parvaneh N, Yeganeh M, Movahedi M, Gharagolou M, et al. Mortality and morbidity in common variable immunodeficiency. J Trop Pediatr 2007;53:32-8.
Yong PF, Tarzi M, Chua I, Grimbacher B, Chee R. Common variable immunodeficiency: An update on etiology and management. Immunol Allergy Clin North Am 2008;28:367-86, ix-x.
Malphettes M, Gérard L, Carmagnat M, Mouillot G, Vince N, Boutboul D, et al. Late-onset combined immune deficiency: A subset of common variable immunodeficiency with severe T cell defect. Clin Infect Dis 2009;49:1329-38.
Orange JS, Hossny EM, Weiler CR, Ballow M, Berger M, Bonilla FA, et al. Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. J Allergy Clin Immunol 2006;117(4 Suppl):S525-53.
Hartung HP, Mouthon L, Ahmed R, Jordan S, Laupland KB, Jolles S. Clinical applications of intravenous immunoglobulins (IVIg)-beyond immunodeficiencies and neurology. Clin Exp Immunol 2009;158 Suppl 1:23-33.
Marques MR, Nunes A, Sousa C, Moura F, Gouveia J, Ramos A. Community-acquired pneumonia in an intensive care unit. Rev Port Pneumol 2010;16:223-35.
Bates CA, Ellison MC, Lynch DA, Cool CD, Brown KK, Routes JM. Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency. J Allergy Clin Immunol 2004;114:415-21.
Bonhomme D, Hammarström L, Webster D, Chapel H, Hermine O, Le Deist F, et al. Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency. J Immunol 2000;165:4725-30.
Cunningham-Rundles C. How I treat common variable immune deficiency. Blood 2010;116:7-15.
Eibl MM. History of immunoglobulin replacement. Immunol Allergy Clin North Am 2008;28:737-64.