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VOLUME 16 , ISSUE 4 ( October, 2012 ) > List of Articles


Chronic subdural hematoma in a child with acute myeloid leukemia after leukocytosis

Mehmet Basmaci, Askin E. Hasturk

Keywords : Acute myeloid leukemia, child, leukocytosis, subdural hematoma

Citation Information : Basmaci M, Hasturk AE. Chronic subdural hematoma in a child with acute myeloid leukemia after leukocytosis. Indian J Crit Care Med 2012; 16 (4):222-224.

DOI: 10.4103/0972-5229.106508

License: CC BY-ND 3.0

Published Online: 01-12-2016

Copyright Statement:  Copyright © 2012; The Author(s).


Severe complications that develop in the early stages in patients with acute leukemia have a mortal course. Bleeding, leukostasis, and less frequently, infections are responsible for early mortality. Hemorrhage is most common in acute leukemia and usually leads to death. Hemorrhage may occur due to chemotherapy or bone marrow transplantation in patients with acute leukemia. Leukocytosis, thrombocytopenia, sepsis, and coagulopathy increase the risk of bleeding. There may be multiple etiologic factors. Subdural or subarachnoid hemorrhage is less common than an intra-axial hemorrhage. The incidence of spontaneous subdural hematoma is higher in patients with leukemia. Although advances in the treatment of platelet transfusion and disseminated intravascular coagulation have decreased the incidence of hemorrhagic complications in patients receiving chemotherapy for acute leukemia, intracranial hemorrhage-related deaths are a significant problem. We discussed the etiology and management of chronic subdural hematoma detected in a two-year-old male patient with Acute Myeloid Leukemia and hyperleukocytosis.

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  1. Acute promyelocytic leukemia: Impact of hemorrhagic complications on response to induction chemotherapy and survival. South Med J 1990;83:1157-61.
  2. Disseminated intravascular coagulation in acute leukemia. Semin Thromb Hemost 2001;27:593-604.
  3. Chronic subdural hematoma in a patient with acute myeloid leukemia and dural metastatic infiltration. Rom J Morphol Embryol 2008;49:259-62.
  4. Childhood leukemia: Centralnervous system abnormalities during and after treatment. AJNR Am J Neuroradiol 1996;17:295-310.
  5. Leukostasis followed by hemorrhage complicating the initiation of chemotherapy in patients with acute myeloid leukemia and hyperleukocytosis: A clinicopathologic report of four cases. Cancer 1999;85:368-74.
  6. Subdural hemorrhage in a child with acute promyelocytic leukemia presenting as subtle headache. J Chin Med Assoc 2005;68:437-40.
  7. Impact of preinduction therapy leukapheresis on treatment outcome in adult acute myelogenous leukemia presenting with hyperleukocytosis. Ann Hematol 2000;79:501-6.
  8. Spontaneous acute subdural hematoma as the initial manifestation of chronic myeloid leukemia. J Neurooncol 2011;101:513-6.
  9. Complications and outcome in childhood acute lymphoblastic leukemia with hyperleukocytosis. Blood 1992;79:871-5.
  10. Hyperleukocytic leukemias: A review of pathophysiology, clinical presentation and management. Leuk Lymphoma 2000;39:1-18.
  11. The effect of the initial management of hyperleukocytosis on early complications and outcome of children with acute lymphoblastic leukemia. J Clin Oncol 1988;6:1425-32.
  12. Recurrent subdural haematoma as the primary and sole manifestation of chronic lymphocytic leukaemia. Br J Neurosurg 1998;12:373-6.
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