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VOLUME 16 , ISSUE 4 ( October, 2012 ) > List of Articles


Acute methotrexate toxicity presenting as multiorgan failure and acute pneumonitis: A rare case report

Ratender K. Singh, Saurabh Saigal

Keywords : Folinic acid, methotrexate, pneumonitis

Citation Information : Singh RK, Saigal S. Acute methotrexate toxicity presenting as multiorgan failure and acute pneumonitis: A rare case report. Indian J Crit Care Med 2012; 16 (4):225-227.

DOI: 10.4103/0972-5229.106509

License: CC BY-ND 3.0

Published Online: 01-12-2016

Copyright Statement:  Copyright © 2012; The Author(s).


Acute methotrexate toxicity rarely presents as medical emergency in form of multiorgan failure. Acute pneumonitis following low-dose methotrexate is rarely reported in literature. It is important to recognize this, as the drug must be discontinued immediately and rescue measures in form of folinic acid and hydration instituted promptly.

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  1. Advances in individual prediction of methotrexate toxicity: A review. Br J Haematol 2009;46:489-503.
  2. A case of acute methotrexate toxicity. Ann Acad Med Singapore 2011;40:97-9.
  3. Life threatening acute pneumonitis during low dose methotrexate treatment for rheumatoid arthritis: A case report and review of the literature. Ann Rheum Dis 1988;47:784-8.
  4. Methotrexate pneumonitis after systemic treatment of ectopic pregnancy. Am J Obstet Gynecol 1997;176:714-5.
  5. Reducing the risk of methotrexate pneumonitis in rheumatoid arthritis. Rheumatology (Oxford) 2004;43:143-7.
  6. Clinical, laboratory, radiographic, and histopathologic features of methotrexate associated lung injury in patients with rheumatoid arthritis: A multicenter study with literature review. Arthritis Rheum 1997;40:1829-37.
  7. Variation of immunological response in methotrexate-induced pneumonitis. Rheumatology (Oxford) 2008;47:1647-50.
  8. Methotrexate induced pneumonitis: A review article. Curr Respir Med Rev 2009;5:12-20.
  9. Acute and chronic effects of methotrexate on hepatic, pulmonary and skeletal systems. Cancer 1979;37:1048-54.
  10. Methotrexate pneumonitis in rheumatoid arthritis: Potential risk factors. Four case reports and a review of the literature. J Rheumatol 1987;14:1164-71.
  11. Methotrexate poisoning. Emerg Med 1996;8:89-92.
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