Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 16 , ISSUE 4 ( October, 2012 ) > List of Articles

CASE REPORT

Hyperlactatemia caused by intra-venous administration of glycerol: A case study

Shinshu Katayama, Shin Nunomiya, Masahiko Wada, Kazuhide Misawa, Shinichiro Tanaka, Kansuke Koyama, Toshitaka Koinuma

Keywords : Glycerol, hyperlactatemia, pyruvic acid

Citation Information : Katayama S, Nunomiya S, Wada M, Misawa K, Tanaka S, Koyama K, Koinuma T. Hyperlactatemia caused by intra-venous administration of glycerol: A case study. Indian J Crit Care Med 2012; 16 (4):241-244.

DOI: 10.4103/0972-5229.106514

License: CC BY-ND 3.0

Published Online: 01-10-2012

Copyright Statement:  Copyright © 2012; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Glyceol® is an intracranial pressure reducing agent composed of 5% fructose and concentrated glycerol. Although rapid administration of fructose is known to cause lactic acidosis, little is known about hyperlactatemia caused by Glyceol® administration itself in adults. We observed an adult case of hyperlactatemia occurred after administration of 200 mL of Glyceol® over a period of 30 minutes. Since there was no evidence of an underlying liver disease or metabolic abnormality, and no findings of sepsis or impaired tissue perfusion, the cause of this condition was deemed to be the rapid loading of fructose contained as a constituent of Glyceol®. We then performed a retrospective chart review and found other 9 cases admitted to Jichi Medical University Hospital ICU and administered Glyceol® during the past year. Their lactate levels increased in general, peaked approximately 45 minutes after Glyceol® administration and returned to pre-administration levels around 3 hours after. Although hyperlactatemia is an important indicator of sepsis and impaired tissue perfusion, caution is required when performing such an assessment in patients being administered Glyceol® .


PDF Share
  1. Glucose production from fructose. Diabetes 1971;20:193-9.
  2. Studies on the mechanism of fructose-induced hyperuricemia in man. Metabolism 1972;21:713-21.
  3. Dangers of intravenous fructose. Lancet 1972;2:1354-7.
  4. Nutritional significance of fructose and sugar alcohols. Annu Rev Nutr 1981;1:437-75.
  5. The use and clinical importance of a substrate-specific electrode for rapid determination of blood lactate concentrations. JAMA 1994;272:1678-85.
  6. Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). Circulation 1970;41:989-1001.
  7. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 1991;99:956-62.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.