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VOLUME 17 , ISSUE 4 ( August, 2013 ) > List of Articles

CASE REPORT

Osmotic demyelination syndrome following slow correction of hyponatremia: Possible role of hypokalemia

Mohammed Ashraf, Parvaiz A. Koul, Umar Hafiz Khan, Rafi A. Jan, Sanaullah Shah, Abdul Baseer Qadri, Burhan Wani, Feroze Ahmad, Sajjad R. Bazaz

Keywords : Electrolyte disturbances, hypokalemia, hyponatremia, locked-in state

Citation Information : Ashraf M, Koul PA, Khan UH, Jan RA, Shah S, Qadri AB, Wani B, Ahmad F, Bazaz SR. Osmotic demyelination syndrome following slow correction of hyponatremia: Possible role of hypokalemia. Indian J Crit Care Med 2013; 17 (4):231-233.

DOI: 10.4103/0972-5229.118433

License: CC BY-ND 3.0

Published Online: 01-08-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

A 47-year-old male presented with hyponatremia that was corrected slowly as per the recommended guidelines. The patient improved initially but went on to develop a quadriparesis with a locked-in state due to a central as well as extrapontine myelinolysis and subsequently succumbed to an intercurrent infective illness. The patient had associated hypokalemia. Hyponatremia can result in central pontine myelinolysis even when the electrolyte disorder is treated slowly, and the concomitant hypokalemia seems to play a contributory role in the pathogenesis of the neurological disorder.


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