Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 17 , ISSUE 5 ( October, 2013 ) > List of Articles

CASE REPORT

A case of pulmonary alveolar proteinosis treated with whole lung lavage

Avdhesh Bansal, Vikas Sikri

Keywords : Granulocyte macrophage colony stimulating factor, pulmonary alveolar proteinosis, Trans Bronchial Lung Biopsy, whole-lung lavage

Citation Information : Bansal A, Sikri V. A case of pulmonary alveolar proteinosis treated with whole lung lavage. Indian J Crit Care Med 2013; 17 (5):314-317.

DOI: 10.4103/0972-5229.120327

License: CC BY-ND 3.0

Published Online: 00-10-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Pulmonary alveolar proteinosis represents a rare syndrome characterized by the accumulation of proteinaceous phospholipid-laden material in the alveoli. This leads to impaired gas exchange and arterial hypoxemia of varying degrees. The diagnosis is confirmed by lung biopsy. Sequential whole-lung lavage (WLL) first described in 1963 is the standard of care. We report a case of a male diagnosed of having pulmonary alveolar proteinosis (PAP) on transbroncial lung biopsy (TBLB). He was treated with sequential WLL (Left followed by right, Left being more involved on chest X-ray) followed by recombinant GM-CSF, with good result.


PDF Share
  1. Rosen SH, Castleman B, Liebow AA. Pulmonary alveolar proteinosis. N Engl J Med 1958;258:1123-42.
  2. Borie R, Danel C, Debray MP, Taille C, Dombert MC, Aubier M, et al. Pulmonary alveolar proteinosis. Eur Respir Rev 2011;20:98-107.
  3. Ben-Dov I, Kishinevski Y, Roznman J, Soliman A, Bishara H, Zelligson, et al. Pulmonary alveolar proteinosis in Israel: Ethnic clustering. Isr Med Assoc J 1999;1:75-8.
  4. Seymour JF, Presneill JJ. Pulmonary alveolar proteinosis: Progress in the first 44 years. Am J Respir Crit Care Med 2002;166:215-35.
  5. Johkoh T, Itoh H, Muller NL, Ichikado K, Nakamura H, Ikezoe J, et al. Crazy-paving appearance at thin-section CT: Spectrum of disease and pathologic findings. Radiology 1999;211:155-60.
  6. Wang BM, Stern EJ, Schmidt RA, Pierson DJ. Diagnosing pulmonary alveolar proteinosis: A review and an update. Chest 1997;111:460-6.
  7. Trapnell BC, Whitsett JA, Nakata K. Pulmonary alveolar proteinosis. N Engl J Med 2003;349:2527-39.
  8. Hamvas A, Nogee LM, Mallory GB Jr, Spray TL, Huddleston CB, August A, et al. Lung transplantation for treatment of infants with surfactant protein B deficiency. J Pediatr 1997;130:231-9.
  9. Du Bois RM, McAllister WA, Branthwaite MA. Alveolar proteinosis: Diagnosis and treatment over a 10-year period. Thorax 1983;38:360-3.
  10. Seymour JF, Presneill JJ, Schoch OD, Downie GH, Moore PE, Doyle IR, et al. Therapeutic efficacy of granulocyte-macrophage colony-stimulating factor in patients with idiopathic acquired alveolar proteinosis. Am J Respir Crit Care Med 2001;163:524-31.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.