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VOLUME 18 , ISSUE 3 ( March, 2014 ) > List of Articles

CASE REPORT

N-acetylcystein in dengue associated severe hepatitis

Buddhika Widyaratna Peiris Habaragamuwa, Palitha Dissanayaka

Keywords : Dengue hepatitis, Dengue fever, N-acetylcystein, severe hepatitis

Citation Information : Habaragamuwa BW, Dissanayaka P. N-acetylcystein in dengue associated severe hepatitis. Indian J Crit Care Med 2014; 18 (3):181-182.

DOI: 10.4103/0972-5229.128712

License: CC BY-ND 3.0

Published Online: 01-01-2014

Copyright Statement:  Copyright © 2014; The Author(s).


Abstract

Although, N-acetylcystein (NAC) has shown benefit in non-acetaminophen related liver failure, it was not well studies in dengue associated severe hepatitis. We report a case of dengue hemorrhagic fever associated severe hepatitis (encephalopathy grade 2-drowsy and intermittent disorientation) treated with NAC resulted in good outcome without hepatic transplantation.

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  1. Mumtaz K, Azam Z, Hamid S, Abid S, Memon S, Ali Shah H, et al. Role of N-acetylcysteine in adults with non-acetaminophen-induced acute liver failure in a center without the facility of liver transplantation. Hepatol Int 2009;3:563-70.
  2. Lee WM, Hynan LS, Rossaro L, Fontana RJ, Stravitz RT, Larson AM, et al. Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. Gastroenterology 2009;137:856-64, 864.e1.
  3. Ling LM, Wilder-Smith A, Leo YS. Fulminant hepatitis in dengue haemorrhagic fever. J Clin Virol 2007;38:265-8.
  4. Sklar GE, Subramaniam M. Acetylcysteine treatment for non-acetaminophen-induced acute liver failure. Ann Pharmacother 2004;38:498-500.
  5. Kumarasena RS, Mananjala Senanayake S, Sivaraman K, de Silva AP, Dassanayake AS, Premaratna R, et al. Intravenous N-acetylcysteine in dengue-associated acute liver failure. Hepatol Int 2010;4:533-4.
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