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VOLUME 18 , ISSUE 5 ( May, 2014 ) > List of Articles

SHORT COMMUNICATION

Current concepts in combination antibiotic therapy for critically ill patients

Arvind Baronia, Armin Ahmed

Keywords : Carbapenem-resistant enterobacteriaceae, combination antibiotic therapy, Klebsiella pneumoniae carbapenemase, sepsis

Citation Information : Baronia A, Ahmed A. Current concepts in combination antibiotic therapy for critically ill patients. Indian J Crit Care Med 2014; 18 (5):310-314.

DOI: 10.4103/0972-5229.132495

License: CC BY-ND 3.0

Published Online: 01-05-2014

Copyright Statement:  Copyright © 2014; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Widespread emergence of multidrug resistant (MDR) bacterial pathogens is a problem of global dimension. MDR infections are difficult to treat and frequently associated with high mortality. More than one antibiotic is commonly used to treat such infections, but scientific evidence does not favor use of combination therapy in most cases. However, there are certain subgroups where combination therapy may be beneficial, e.g. sepsis due to carbapenem-resistant Enterobacteriaceae (CRE), bacteremic pneumococcal pneumonia, and patients with multiple organ failure. Well-designed prospective studies are needed to clearly define the role of combination therapy in these subgroups.


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