Citation Information :
Bhatia V, Saini D, Khillan V, Rathor N, Bal CK, Daman R, Sarin SK. Spontaneous cryptococcal peritonitis with fungemia in patients with decompensated cirrhosis: Report of two cases. Indian J Crit Care Med 2014; 18 (8):536-539.
Cryptococcus neoformans is encapsulated yeast that predominately infects immunocompromised individuals. Liver disease is an under-recognized predisposition for cryptococcal disease. We report two nonalcoholic, nondiabetic, and human immunodeficiency virus - negative cirrhotic patients, with spontaneous cryptococcal peritonitis. Cryptococcus infection was diagnosed by culture of ascitic fluid and peripheral blood in both. We treated the first patient with amphotericin-B, but he expired. The second patient with earlier diagnosis, survived to discharge with fluconazole treatment. We suggest a high clinical suspicion for Cryptococcus as a possible etiology of spontaneous peritonitis in cirrhotic patients.
Saif MW, Raj M. Cryptococcal peritonitis complicating hepatic failure: Case report and review of the literature. J Appl Res 2006;6:43-50.
Yehia BR, Eberlein M, Sisson SD, Hager DN. Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: A case report. Cases J 2009;2:170.
Singh P, Joshi D, Gangane N. Cryptococcus peritonitis a rare manifestation in HIV positive host: A case report. Diagn Cytopathol 2011;39:365-7.
Han L, Husain M, Fairfax MR, Al-Abbadi MA. Cytological diagnosis of cryptococcal peritonitis on peritoneal fluid. Diagn Cytopathol 2007;35:670-1.
Jean SS, Wang JL, Wang JT, Fang CT, Chen YC, Chang SC. Cryptococcus neoformans peritonitis in two patients with liver cirrhosis. J Formos Med Assoc 2005;104:39-42.
Utili R, Tripodi MF, Ragone E, Casillo R, Pasquale G, De Santo L, et al. Hepatic cryptococcosis in a heart transplant recipient. Transpl Infect Dis 2004;6:33-6.
Liu PY, Yang Y, Shi ZY. Cryptococcal liver abscess: A case report of successful treatment with amphotericin-B and literature review. Jpn J Infect Dis 2009;62:59-60.
Méndez-Sánchez N, Pichardo-Bahena R, Castrejón HV, Berron-Pérez RD, Hernández-Bautista VM, Soto-Ramírez L, et al. Necrotizing hepatitis and intrahepatic cholestasis associated to Cryptococcus sp. and Pneumocystis carinii. Ann Hepatol 2006;5:289-90.
Lin JI, Kabir MA, Tseng HC, Hillman N, Moezzi J, Gopalswamy N. Hepatobiliary dysfunction as the initial manifestation of disseminated cryptococcosis. J Clin Gastroenterol 1999;28:273-5.
Gollan JL, Davidson GP, Anderson K, White TA, Kimber CL. Visceral cryptococcosis without central nervous system or pulmonary involvement: Presentation as hepatitis. Med J Aust 1972;1:469-71.
Procknow JJ, Benfield JR, Rippon JW, Diener CF, Archer FL. Cryptococcal hepatitis presenting as a surgical emergency. First isolation of Cryptococcus neoformans from point source in Chicago. JAMA 1965;191:269-74.
Singh N, Husain S, De Vera M, Gayowski T, Cacciarelli TV. Cryptococcus neoformans infection in patients with cirrhosis, including liver transplant candidates. Medicine (Baltimore) 2004;83:188-92.
Chuang YM, Ho YC, Chang HT, Yu CJ, Yang PC, Hsueh PR. Disseminated cryptococcosis in HIV-uninfected patients. Eur J Clin Microbiol Infect Dis 2008;27:307-10.
Jean SS, Fang CT, Shau WY, Chen YC, Chang SC, Hsueh PR, et al. Cryptococcaemia: Clinical features and prognostic factors. QJM 2002;95:511-8.
Cleophas V, George V, Mathew M, Samal SC, Chandy GM. Spontaneous fungal peritonitis in patients with hepatitis B virus-related liver disease. J Clin Gastroenterol 2000;31:77-9.
Mutreja D, Malhotra R, Dutta U. Cryptococcus in pleural fluid cytology in a patient with hepatitis B virus-associated chronic liver disease. J Cytol 2011;28:145-6.