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VOLUME 18 , ISSUE 9 ( September, 2014 ) > List of Articles

CASE REPORT

Osmotic demyelination syndrome in a normonatremic patient of chronic kidney disease

Atul Abhishek Jha, Vineet Behera, Anantharam Jairam, Krishna Venkatesh Baliga

Keywords : Central pontine myelinosis, chronic kidney disease, hyponatremia, normonatremia, osmotic demyelination syndrome

Citation Information : Jha AA, Behera V, Jairam A, Baliga KV. Osmotic demyelination syndrome in a normonatremic patient of chronic kidney disease. Indian J Crit Care Med 2014; 18 (9):609-611.

DOI: 10.4103/0972-5229.140153

License: CC BY-ND 3.0

Published Online: 01-09-2014

Copyright Statement:  Copyright © 2014; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Osmotic Demyelination Syndrome (ODS) is associated with rapid correction of hyponatremia or fluid shifts, and is characterized by neurological involvement related to pons, brainstem or other areas of the brain. All possible measures should be taken to prevent this serious disorder. Diagnosing this condition early is very important and requires a high index of suspicion. The treatment is purely supportive and most patients may show dramatic recovery. ODS occurring in normonatremic and hypernatremic patients is very rare. We report a case of an 18-year-old boy of end-stage renal disease who presented with an episode of acute gastroenteritis. He was managed with aggressive intravenous fluids, hemodialysis and other supportive therapy. But, he developed altered sensorium and seizures that progressed to features of spastic quadriparesis and lower cranial nerve palsy. Neuroimaging showed hyperintensities in pons and midbrain suggestive of ODS. The patient had normal sodium levels at all times and had no evidence of hyponatremia. The patient was managed with hemodialysis, physiotherapy and other conservative measures and had a gradual clinical and radiological recovery.


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