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VOLUME 19 , ISSUE 10 ( 2015 ) > List of Articles

CASE REPORT

A rare case of idiopathic cluster of differentiation 4 + T-cell lymphocytopenia presenting with disseminated tubercular infection

Vikas Sikri, Alok Jain

Keywords : disseminated tuberculosis, idiopathic cluster of differentiation 4 + T-cell lymphocytopenia, immunodeficiency, opportunistic infections,Cryptococcal meningitis

Citation Information : Sikri V, Jain A. A rare case of idiopathic cluster of differentiation 4 + T-cell lymphocytopenia presenting with disseminated tubercular infection. Indian J Crit Care Med 2015; 19 (10):621-623.

DOI: 10.4103/0972-5229.167054

License: CC BY-ND 3.0

Published Online: 00-10-2015

Copyright Statement:  Copyright © 2015; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Idiopathic cluster of differentiation 4 + (CD4 +) T-cell lymphocytopenia is a rare heterogeneous clinical syndrome characterized by low absolute CD4 counts on two different occasions without any evidence of other known cause of immunodeficiency including human immunodeficiency virus (HIV), infections or drugs associated with fall in CD4 + count. Also referred to as severe unexplained HIV seronegative immune suppression by the World Health Organization, it was first described by Centers for Disease Control in 1992 in patients with opportunistic infections who were negative for HIV but had low CD4 counts. Patients typically present with opportunistic infections, malignancies, or autoimmune disorders. There have been case reports on opportunistic infections such as cryptococcal meningitis or non-Mycobacterium tuberculosis infections in these patients. However, no case of disseminated M. tuberculosis has been reported as such in Indian literature. We present a case of disseminated tuberculosis with low CD4 counts without any evidence of HIV infection.


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