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VOLUME 19 , ISSUE 3 ( 2015 ) > List of Articles


Osmotic demyelination syndrome in Intensive Care Unit

Neha Singh, Anand Kumar, Arvind Kumar Baronia, Parnandi Bhaskar Rao

Keywords : Demyelination, hyponatremia, Intensive Care Unit, osmotic, syndrome

Citation Information : Singh N, Kumar A, Baronia AK, Rao PB. Osmotic demyelination syndrome in Intensive Care Unit. Indian J Crit Care Med 2015; 19 (3):166-169.

DOI: 10.4103/0972-5229.152760

License: CC BY-ND 3.0

Published Online: 01-02-2016

Copyright Statement:  Copyright © 2015; The Author(s).


Dyselectrolytemia, especially hyponatremia is a common occurrence in hospitalized patients, and a number of dreaded complications arise out of the disorder itself and its treatment. Osmotic demyelination syndrome develops secondary to rapid correction of hyponatremia. As the disease is rare and available literature from Intensive Care Units are limited, we report our retrospective observation over 5 years. Overall incidence was 2.5% with altered sensorium and hypokalemia as most common symptom and associated factor respectively. Isolated pontine involvement was in 41% and combined pontine, and extra-pontine lesions were found in 23% of cases. All patients received supportive therapy; out of which 2 died and complete neurological recovery was seen in 24% of patients. Our findings suggest that a well organized supportive therapy and multidisciplinary approach is of more concern than many available therapeutic modalities which are still to be proved.

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