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VOLUME 19 , ISSUE 7 ( 2015 ) > List of Articles


The rabies early death phenomenon: A report of ineffective administration of rabies vaccine during symptomatic disease

Mahmoud Sadeghi, Shams-ali Hadizadeh Moallem, Elham Yousefi-Abdolmaleki, Mohammad Montazeri

Keywords : Early death, postexposure vaccine, rabies

Citation Information : Sadeghi M, Moallem SH, Yousefi-Abdolmaleki E, Montazeri M. The rabies early death phenomenon: A report of ineffective administration of rabies vaccine during symptomatic disease. Indian J Crit Care Med 2015; 19 (7):422-424.

DOI: 10.4103/0972-5229.160292

License: CC BY-ND 3.0

Published Online: 01-06-2016

Copyright Statement:  Copyright © 2015; The Author(s).


It was reported that in some individuals who received postexposure rabies vaccine, clinical features of rabies developed at the shorter time compared to individuals who were exposed, but not received the vaccine, which called \"early death\" phenomenon. We reported an early death phenomenon in a 67-year-old woman who was bitten by a jackal, although receiving three dose of rabies vaccine. Results show that the immune response to rabies has a dual role, sometimes has a favorable effect on survival but sometimes amplification the disease.

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