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VOLUME 19 , ISSUE 8 ( 2015 ) > List of Articles

RESEARCH ARTICLE

Prognostic significance of early platelet count decline in preterm newborns

Abeer Abd Elmoneim, Mohammed Zolaly, Ehab Abd El-Moneim, Eisa Sultan

Keywords : length of stay, neonatal infections, neonatal outcome, platelets, preterm, thrombocytopenia,Intraventricular hemorrhage

Citation Information : Elmoneim AA, Zolaly M, El-Moneim EA, Sultan E. Prognostic significance of early platelet count decline in preterm newborns. Indian J Crit Care Med 2015; 19 (8):456-461.

DOI: 10.4103/0972-5229.162462

License: CC BY-ND 3.0

Published Online: 00-08-2015

Copyright Statement:  Copyright © 2015; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Objectives: Decline of platelets with or without thrombocytopenia is observed in critically ill preterm newborns. Prognostic significance of platelets count in Neonatal Intensive Care Unit focused on outcome after thrombocytopenia. We aimed to estimate the changes in platelets count within the first 7 days of life in preterm newborns and its relation to final outcomes. Methods: Retrospectively, the platelets count during the first 7 days of life, and its association with mortality, length of stay among survivors (LOS), and later severe morbidities were determined. Appropriate regression analyses were used to examine possible relations between studied variables. Results and Discussion: Platelets drop that did not reach thrombocytopenia level in the first 7 days of life happened in 61.7%. Platelets count drop in the first 7 days of life was a predictor of mortality, LOS, and major morbidities such as intraventricular hemorrhage and necrotizing enterocolitis. Conclusions: Platelets count drop within the first 7 days of life independent of thrombocytopenia can be used to predict increased mortality, LOS, and the development of later severe morbidities in critically ill preterm neonates.


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