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VOLUME 20 , ISSUE 10 ( 2016 ) > List of Articles

CASE REPORT

Successful engraftment after hematopoietic stem cell transplantation with infusion of donor stem cells through the extracorporeal membrane oxygenation circuit

Pilar Anton-Martin, Cindy Darnell-Bowens, Victor Aquino, Teresa Jones, Lakshmi Raman

Keywords : Engraftment, extracorporeal membrane oxygenation, hematopoietic stem cell transplantation, Wiskott-Aldrich syndrome

Citation Information : Anton-Martin P, Darnell-Bowens C, Aquino V, Jones T, Raman L. Successful engraftment after hematopoietic stem cell transplantation with infusion of donor stem cells through the extracorporeal membrane oxygenation circuit. Indian J Crit Care Med 2016; 20 (10):617-619.

DOI: 10.4103/0972-5229.192062

License: CC BY-ND 3.0

Published Online: 01-10-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency due to mutations in the WAS gene expressed in hematopoietic cells. Hematopoietic stem cell transplantation (HSCT) is the treatment of choice when an appropriate human leukocyte antigen-matched donor is available. The use of the extracorporeal membrane oxygenation (ECMO) circuit to infuse donor cells for HSCT has not been previously published in the literature. We describe a case of a child who had successful engraftment after HSCT with infusion of the donor stem cells through the ECMO circuit.


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  1. Massaad MJ, Ramesh N, Geha RS. Wiskott-Aldrich syndrome: A comprehensive review. Ann N Y Acad Sci 2013;1285:26-43.
  2. Standen GR. Wiskott-Aldrich syndrome: New perspectives in pathogenesis and management. J R Coll Physicians Lond 1988;22:80-3.
  3. Di Nardo M, Locatelli F, Palmer K, Amodeo A, Lorusso R, Belliato M, et al. Extracorporeal membrane oxygenation in pediatric recipients of hematopoietic stem cell transplantation: An updated analysis of the Extracorporeal Life Support Organization experience. Intensive Care Med 2014;40:754-6.
  4. Gow KW, Lao OB, Leong T, Fortenberry JD. Extracorporeal life support for adults with malignancy and respiratory or cardiac failure: The Extracorporeal Life Support experience. Am J Surg 2010;199:669-75.
  5. Gow KW, Wulkan ML, Heiss KF, Haight AE, Heard ML, Rycus P, et al. Extracorporeal membrane oxygenation for support of children after hematopoietic stem cell transplantation: The Extracorporeal Life Support Organization experience. J Pediatr Surg 2006;41:662-7.
  6. Morris SH, Haight AE, Kamat P, Fortenberry JD. Successful use of extracorporeal life support in a hematopoietic stem cell transplant patient with diffuse alveolar hemorrhage. Pediatr Crit Care Med 2010;11:e4-7.
  7. Liao WI, Tsai SH, Chiu SK. Successful use of extracorporeal membrane oxygenation in a hematopoietic stem cell transplant patient with idiopathic pneumonia syndrome. Respir Care 2013;58:e6-10.
  8. Stretch R, Bonde P. Successful use of extracorporeal membrane oxygenation for respiratory failure in pulmonary chronic graft-versus-host disease. ASAIO J 2014;60:122-3.
  9. Koinuma T, Nunomiya S, Wada M, Koyama K, Suzuki T. Concurrent treatment with a tumor necrosis factor-alpha inhibitor and veno-venous extracorporeal membrane oxygenation in a post-hematopoietic stem cell transplant patient with idiopathic pneumonia syndrome: A case report. J Intensive Care 2014;2:48.
  10. Di Nardo M, Li Pira G, Amodeo A, Cecchetti C, Giorda E, Ceccarelli S, et al. Adoptive immunotherapy with antigen-specific T cells during extracorporeal membrane oxygenation (ECMO) for adenovirus-related respiratory failure in a child given haploidentical stem cell transplantation. Pediatr Blood Cancer 2014;61:376-9.
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