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VOLUME 20 , ISSUE 12 ( 2016 ) > List of Articles

CASE REPORT

Acute pesticide ingestion managed with yohimbine as a rescue therapy

Deven Juneja

Keywords : Amitraz poisoning, poisoning, yohimbine

Citation Information : Juneja D. Acute pesticide ingestion managed with yohimbine as a rescue therapy. Indian J Crit Care Med 2016; 20 (12):739-741.

DOI: 10.4103/0972-5229.195716

License: CC BY-ND 3.0

Published Online: 01-12-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Amitraz is used as a pesticide in agricultural and veterinary medicine. It is primarily a central α2 adrenergic agonist and known to cause central nervous system depression, convulsions, respiratory depression, and bradycardia on severe intoxication. We report a case of a 3-year-old child who presented with accidental ingestion of amitraz solution with signs of severe poisoning. There is no specific antidote of amitraz poisoning in humans, however, animal experiments with α2 adrenergic antagonists such as yohimbine and atimepazole have been successful. The child was managed besides intensive management with enteral yohimbine, and he regained consciousness in 18 h and was successfully weaned off mechanical ventilation.


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  1. Yilmaz HL, Yildizdas DR. Amitraz poisoning, an emerging problem: Epidemiology, clinical features, management, and preventive strategies. Arch Dis Child 2003;88:130-4.
  2. Aydin K, Per H, Kurtoglu S, Poyrazoglu MH, Narin N, Aslan D. Amitraz poisoning in children. Eur J Pediatr 2002;161:349-50.
  3. Doganay Z, Aygun D, Altintop L, Guven H, Bildik F. Basic toxicological approach has been effective in two poisoned patients with amitraz ingestion: Case reports. Hum Exp Toxicol 2002;21:55-7.
  4. Aydin K, Kurtoglu S, Poyrazoglu MH, Uzüm K, Ustünbas HB, Hallaç IK. Amitraz poisoning in children: Clinical and laboratory findings of eight cases. Hum Exp Toxicol 1997;16:680-2.
  5. Eizadi-Mood N, Sabzghabaee AM, Gheshlaghi F, Yaraghi A. Amitraz poisoning treatment: Still supportive? Iran J Pharm Res 2011;10:155-8.
  6. Kleinman ME, Chameides L, Schexnayder SM, Samson RA, Hazinski MF, Atkins DL, et al. Part 14: Pediatric advanced life support: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010;122 18 Suppl 3:S876-908.
  7. Abu-Basha EA, Yibchok-Anun S, Hopper DL, Hsu WH. Effects of the pesticide amitraz and its metabolite BTS 27271 on insulin and glucagon secretion from the perfused rat pancreas: Involvement of alpha2D-adrenergic receptors. Metabolism 1999;48:1461-9.
  8. Andrade SF, Sakate M. The comparative efficacy of yohimbine and atipamezole to treat amitraz intoxication in dogs. Vet Hum Toxicol 2003;45:124-7.
  9. Andrade SF, Sakate M, Laposy CB, Sangiorgio F. Yohimbine and atipamezole on the treatment of experimentally induced amitraz intoxication in cats. Int J Appl Vet Med 2006;4:200-8.
  10. Young FM, Menadue MF, Lavranos TC. Effects of the insecticide amitraz, an alpha2-adrenergic receptor agonist, on human luteinized granulosa cells. Hum Reprod 2005;20:3018-25.
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