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VOLUME 20 , ISSUE 12 ( 2016 ) > List of Articles


Acute pesticide ingestion managed with yohimbine as a rescue therapy

Keywords : Amitraz poisoning, poisoning, yohimbine

Citation Information : Acute pesticide ingestion managed with yohimbine as a rescue therapy. Indian J Crit Care Med 2016; 20 (12):739-741.

DOI: 10.4103/0972-5229.195716

License: CC BY-ND 3.0

Published Online: 01-11-2017

Copyright Statement:  Copyright © 2016; The Author(s).


Amitraz is used as a pesticide in agricultural and veterinary medicine. It is primarily a central α2 adrenergic agonist and known to cause central nervous system depression, convulsions, respiratory depression, and bradycardia on severe intoxication. We report a case of a 3-year-old child who presented with accidental ingestion of amitraz solution with signs of severe poisoning. There is no specific antidote of amitraz poisoning in humans, however, animal experiments with α2 adrenergic antagonists such as yohimbine and atimepazole have been successful. The child was managed besides intensive management with enteral yohimbine, and he regained consciousness in 18 h and was successfully weaned off mechanical ventilation.

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