Citation Information :
Saxena P, Kumar K, Mittal S, Goyal N, Trikha S, Vashisth A. Acute fibrinous and organizing pneumonia: A rare form of nonbacterial pneumonia. Indian J Crit Care Med 2016; 20 (4):245-247.
Acute fibrinous and organizing pneumonia (AFOP) is a rare disease characterized by bilateral basilar infiltrates and histological findings of organizing pneumonia and intra-alveolar fibrin in the form of \"fibrin balls.\" Here, we report a 43-year-old female with complaints of fever, dry cough, and shortness of breath with hypoxemia. High-resolution computed tomography thorax revealed diffuse confluent consolidation in bilateral lung zones. Bronchoscopy and transbronchial biopsy revealed features of AFOP. With prednisolone treatment, there was an improvement in her condition. AFOP is a rare disease and should be taken into consideration and differential diagnosis of severe acute pneumonias with no significant comorbidities.
Beasley MB, Franks TJ, Galvin JR, Gochuico B, Travis WD. Acute fibrinous and organizing pneumonia: A histological pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med 2002;126:1064-70.
Damas C, Morais A, Moura CS, Marques A. Acute fibrinous and organizing pneumonia. Rev Port Pneumol 2006;12:615-20.
Voloudaki AE, Bouros DE, Froudarakis ME, Datseris GE, Apostolaki EG, Gourtsoyiannis NC. Crescentic and ring-shaped opacities. CT features in two cases of bronchiolitis obliterans organizing pneumonia (BOOP). Acta Radiol 1996;37:889-92.
Labarinas S, Gumy-Pause F, Rougemont AL, Baerlocher G, Leibundgut EO, Porret N, et al. Is acute fibrinous and organizing pneumonia the expression of immune dysregulation? J Pediatr Hematol Oncol 2013;35:139-43.
Valim V, Rocha RH, Couto RB, Paixão TS, Serrano EV. Acute fibrinous and organizing pneumonia and undifferentiated connective tissue disease: A case report. Case Rep Rheumatol 2012;2012:549298.
Hariri LP, Unizony S, Stone J, Mino-Kenudson M, Sharma A, Matsubara O, et al. Acute fibrinous and organizing pneumonia in systemic lupus erythematosus: A case report and review of the literature. Pathol Int 2010;60:755-9.
Sauter JL, Butnor KJ. Expanding the spectrum of pulmonary histopathological manifestations of anti-synthetase syndrome: Anti-EJ-associated acute fibrinous and organizing pneumonia. Histopathology 2014;65:581-2.
Guimarães C, Sanches I, Ferreira C. Acute fibrinous and organising pneumonia. BMJ Case Rep 2012;2012. pii: Bcr0120113689.
Bhatti S, Hakeem A, Torrealba J, McMahon JP, Meyer KC. Severe acute fibrinous and organizing pneumonia (AFOP) causing ventilatory failure: Successful treatment with mycophenolate mofetil and corticosteroids. Respir Med 2009;103:1764-7.
Mittal V, Kulshrestha R, Arya A, Bajaj P. Acute fibrinous and organising pneumonia presenting as complete lung consolidation. Singapore Med J 2011;52:e88-90.
Kuza C, Matheos T, Kathman D, Heard SO. Life after acute fibrinous and organizing pneumonia: A case report of a patient 30 months after diagnosis and review of the literature. J Crit Care 2016;31:255-61.