Citation Information :
Chauhan SG, Sood A, Kaushik A, Nagar VS, Kadu R, Patel DV. Clinically HIV but negative serology: Think of idiopathic CD4+ lymphocytopenia. Indian J Crit Care Med 2016; 20 (6):371-373.
idiopathic CD4+ lymphocytopenia (ICL) is a rare disorder characterized by the presence of depleted CD4 cell line without the presence of HIV infection. Slight male preponderance is noticed and is usually seen in the middle age group. Opportunistic infections are the reason for their discovery and here we describe a case where a man was diagnosed as having Pneumocystis jiroveci pneumonia and oral candidiasis.
Sharma A, Lal V, Modi M, Khurana D, Bal S, Prabhakar S. Idiopathic CD4+ lymphocytopenia presenting as refractory cryptococcal meningitis. Ann Indian Acad Neurol 2010;13:136-8.
Netea MG, Brouwer AE, Hoogendoorn EH, Van der Meer JW, Koolen M, Verweij PE, et al. Two patients with cryptococcal meningitis and idiopathic CD4 lymphopenia: Defective cytokine production and reversal by recombinant interferon-gamma therapy. Clin Infect Dis 2004;39:e83-7.
Scott-Algara D, Balabanian K, Chakrabarti LA, Mouthon L, Dromer F, Didier C, et al. Idiopathic CD4+ T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4. Blood 2010;115:3708-17.
Zonios DI, Falloon J, Bennett JE, Shaw PA, Chaitt D, Baseler MW, et al. Idiopathic CD4+ lymphocytopenia: Natural history and prognostic factors. Blood 2008;112:287-94.
Zonios D, Sheikh V, Sereti I. Idiopathic CD4+ lymphocytopenia: A case of missing, wandering or ineffective T cells. Arthritis Res Ther 2012;14:222.
Hamidieh AA, Pourpak Z, Hamdi A, Nabavi M, Ghavamzadeh A. Successful fludarabine-based hematopoietic stem cell transplantation in a pediatric patient with idiopathic CD4+ lymphocytopenia. Pediatr Transplant 2013;17:E109-11.
