Volatile anesthetic for the control of posthypoxic refractory myoclonic status
Vivek Rayadurg, Radhakrishnan Muthuchellappan, Umamaheshwara Rao
Hypoxia, isoflurane, Lance-Adams syndrome, myoclonus, refractory status epilepticus
Citation Information :
Rayadurg V, Muthuchellappan R, Rao U. Volatile anesthetic for the control of posthypoxic refractory myoclonic status. Indian J Crit Care Med 2016; 20 (8):485-488.
CC BY-ND 3.0
Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.
Posthypoxic myoclonus (Lance-Adams syndrome) is characterized by myoclonus involving multiple muscle groups which is resistant to most conventional antiepileptic drugs. We present a case of hypoxic brain injury-induced myoclonic status epilepticus successfully controlled with isoflurane. The antimyoclonic effects of isoflurane are likely due to potentiation of inhibitory postsynaptic GABA
A receptor-mediated currents and its effects on thalamocortical pathways. It is effective even when intravenous agents fail to control myoclonus. It may be a useful alternative to intravenous anesthetics as a third tier therapy in patients with refractory status myoclonus.
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