Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RM, Santhakumaran S, et al. Levosimendan for the prevention of acute organ dysfunction in sepsis. N Engl J Med 2016;375:1638-48.
Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of conservative vs. conventional oxygen therapy on mortality among patients in an Intensive Care Unit: The oxygen-ICU randomized clinical trial. JAMA 2016;316:1583-9.
Timsit JF, Azoulay E, Schwebel C, Charles PE, Cornet M, Souweine B, et al. Empirical micafungin treatment and survival without invasive fungal infection in adults with ICU-acquired sepsis, Candida colonization, and multiple organ failure: The EMPIRICUS randomized clinical trial. JAMA 2016;316:1555-64.
Hutchinson PJ, Kolias AG, Timofeev IS, Corteen EA, Czosnyka M, Timothy J, et al. Trial of decompressive craniectomy for traumatic intracranial hypertension. N Engl J Med 2016;375:1119-30.
Keh D, Trips E, Marx G, Wirtz SP, Abduljawwad E, Bercker S, et al. Effect of hydrocortisone on development of shock among patients with severe sepsis: The HYPRESS randomized clinical trial. JAMA 2016;316:1775-85.
Hjortrup PB, Haase N, Bundgaard H, Thomsen SL, Winding R, Pettilä V, et al. Restricting volumes of resuscitation fluid in adults with septic shock after initial management: The CLASSIC randomised, parallel-group, multicentre feasibility trial. Intensive Care Med 2016;42:1695-705.
Hernández G, Vaquero C, Colinas L, Cuena R, González P, Canabal A, et al. Effect of postextubation high-flow nasal cannula vs. noninvasive ventilation on reintubation and postextubation respiratory failure in high-risk patients: A randomized clinical trial. JAMA 2016;316:1565-74.
Ferguson ND. Oxygen in the ICU: Too much of a good thing? JAMA 2016;316:1553-4.
Yende S, Thompson BT. Evaluating glucocorticoids for sepsis: Time to change course. JAMA 2016;316:1769-71.
Siddharthan T, Karakousis PC, Checkley W. Empirical antifungal therapy in critically Ill patients with sepsis: Another case of less is more in the ICU. JAMA 2016;316:1549-50.
Kapadia FN, Kapoor R. Ten pitfalls in intensive care. India: MacMillan Medical Communication; 2016.
