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VOLUME 21 , ISSUE 10 ( 2017 ) > List of Articles

RESEARCH ARTICLE

The effects of atorvastatin on inflammatory responses and mortality in septic shock: A single-center, randomized controlled trial

Sudeep Kumar, Arvind Kumar Baronia, Ratender Singh

Keywords : Inflammatory biomarkers, mortality, septic shock, statins

Citation Information : Kumar S, Baronia A K, Singh R. The effects of atorvastatin on inflammatory responses and mortality in septic shock: A single-center, randomized controlled trial. Indian J Crit Care Med 2017; 21 (10):646-654.

DOI: 10.4103/ijccm.IJCCM_474_16

License: CC BY-ND 3.0

Published Online: 01-10-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim of the Study: Pleiotropic effect of statins can modulate inflammation in septic shock. We tested the hypothesis whether statins can reduce mortality in septic shock. Patients and Methods: We conducted a randomized double-blinded trial with treatment (40 mg dose of atorvastatin for 7 days) and control (placebo) arm in adult septic shock patients admitted to the Intensive Care Unit. Primary (28-day mortality) and secondary (vasopressor-, ventilation-, and renal replacement therapy-free days) outcomes, with lipid profile and adverse effects, were documented. Inflammatory biomarkers (interleukin [IL]-1, IL-6, tumor-necrosis-factor [TNF]-α, interferon [IFN], and C-reactive protein [CRP]), were also measured before (day 1 [D1]) and after start of trial drug (D4 and D7). Results: Seventy-three septic shock patients with 36 and 37 included in the atorvastatin and placebo group, respectively. Both groups were equally matched. Twenty-eight-day mortality, event-free days, lipid profile, and adverse effects were also not significantly different between groups. Reduced levels of IL-1, IL-6, TNF-α, IFN, and CRP were observed in the atorvastatin group. Also observed were significant day-wise changes in inflammatory biomarkers. Conclusions: Atorvastatin-induced changes in inflammatory biomarkers did not confer mortality benefit in septic shock (ClinicalTrials.govNCT02681653).


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