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VOLUME 21 , ISSUE 10 ( 2017 ) > List of Articles


Serum vitamin D status and outcome in critically Ill children

Nazik Asilioglu, Halit Çiğdem, Sükrü Paksu

Keywords : 25-hydroxyvitamin D, illness severity, mortality, pediatric intensive care

Citation Information : Asilioglu N, Çiğdem H, Paksu S. Serum vitamin D status and outcome in critically Ill children. Indian J Crit Care Med 2017; 21 (10):660-664.

DOI: 10.4103/ijccm.IJCCM_153_17

License: CC BY-ND 3.0

Published Online: 01-01-2019

Copyright Statement:  Copyright © 2017; The Author(s).


Background: Vitamin D is a pleiotropic hormone essential for optimal health. Critical illness in children is a major cause of significant health-care utilization and mortality around the world. The association of Vitamin D deficiency (VDD) in critically ill adults has been well-studied, in comparison, the importance of Vitamin D in pediatric critical illness has been much less studied. Aim and Objectives: This study aimed to assess Vitamin D status and its determinants in patients admitted to a pediatric intensive care unit (PICU) in North of Turkey. We also investigated the association between Vitamin D status and clinical outcomes. Materials and Methods: All patients aged 1 month to 18 years admitted to the PICU of a tertiary care hospital who had levels of 25-hydroxy Vitamin D available within 24 h of admission were included in this retrospective study. VDD was defined as <20 ng/mL levels. Results: VDD was observed in 120 (58.5%) children. In multivariable linear regression model, only identified patient age and winter season as statistically associated with VDD. Vitamin D deficient patients were older and heavier and were more likely to receive catecholamine. There was no association between Vitamin D deficiency and other illness severity factors including mortality. Conclusions: Hypovitaminosis D occurrence was high in critically ill children and was associated with higher vasopressor requirement but not with other markers of illness severity including mortality.

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