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VOLUME 21 , ISSUE 12 ( 2017 ) > List of Articles

CASE REPORT

Cerebral venous thrombosis after intravenous immunoglobulin therapy in immune thrombocytopenic purpura

P. V. Shiji, Chandni Radhakrishnan

Keywords : Immune thrombocytopenic purpura, intravenous immunoglobulin, venous thrombosis

Citation Information : Shiji PV, Radhakrishnan C. Cerebral venous thrombosis after intravenous immunoglobulin therapy in immune thrombocytopenic purpura. Indian J Crit Care Med 2017; 21 (12):869-871.

DOI: 10.4103/ijccm.IJCCM_308_17

License: CC BY-ND 3.0

Published Online: 01-12-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

A common misconception is that immune thrombocytopenic purpura (ITP) causes only bleeding diathesis. From this case vignette of a young male with ITP who had cerebral venous thrombosis, we highlight the importance of considering venous thrombosis in such patients when they present with focal cerebral signs.


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  1. Psaila B, Petrovic A, Page LK, Menell J, Schonholz M, Bussel JB, et al. Intracranial hemorrhage (ICH) in children with immune thrombocytopenia (ITP): Study of 40 cases. Blood 2009;114:4777-83.
  2. Takagi S, Suzuki I, Watanabe S. Risk of thromboembolism in patients with immune thrombocytopenia. J Hematol Thromboembolic Dis 2015;3:1-9.
  3. Cotillon M, Lebas A, Blanc T, Schneider P, Vannier JP, Buchbinder N, et al. Cerebral venous thrombosis and immune thrombocytopenia in a 7-year-old girl: A fortuitous association?. Arch Pediatr 2014;21:1367-9.
  4. Vucic S, Chong PS, Dawson KT, Cudkowicz M, Cros D. Thromboembolic complications of intravenous immunoglobulin treatment. Eur Neurol 2004;52:141-4.
  5. Marie I, Maurey G, Hervé F, Hellot MF, Levesque H. Intravenous immunoglobulin-associated arterial and venous thrombosis; report of a series and review of the literature. Br J Dermatol 2006;155:714-21.
  6. Dalakas MC. High-dose intravenous immunoglobulin and serum viscosity: Risk of precipitating thromboembolic events. Neurology 1994;44:223-6.
  7. Reinhart WH, Berchtold PE. Effect of high-dose intravenous immunoglobulin therapy on blood rheology. Lancet 1992;339:662-4.
  8. Wolberg AS, Kon RH, Monroe DM, Hoffman M. Coagulation factor XI is a contaminant in intravenous immunoglobulin preparations. Am J Hematol 2000;65:30-4.
  9. Ammann EM, Haskins CB, Fillman KM, Ritter RL, Gu X, Winiecki SK, et al. Intravenous immune globulin and thromboembolic adverse events: A systematic review and meta-analysis of RCTs. Am J Hematol 2016;91:594-605.
  10. Kayyali HR, Abdelmoity AT, Morriss MC, Graf WD. Cerebral venous thrombosis after immune thrombocytopenic purpura and anti-D immune globulin therapy. J Child Neurol 2008;23:325-30.
  11. Johannesdottir SA, Horváth-Puhó E, Dekkers OM, Cannegieter SC, Jørgensen JO, Ehrenstein V, et al. Use of glucocorticoids and risk of venous thromboembolism: A nationwide population-based case-control study. JAMA Intern Med 2013;173:743-52.
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