Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 21 , ISSUE 3 ( 2017 ) > List of Articles


Toxic Epidermal Necrolysis and Acute Kidney Injury due to Glyphosate Ingestion

J Indirakshi, A Sunnesh, M Aruna, M. Hari Krishna Reddy, Anil C. V. Kumar, V Sarat Chandra, B Sangeetha, D.T. Katyarmal, R Ram, V. Siva Kumar

Keywords : Acute kidney injury, glyphosate, hemodialysis, toxic epidermal necrolysis

Citation Information : Indirakshi J, Sunnesh A, Aruna M, Reddy MH, Kumar AC, Chandra VS, Sangeetha B, Katyarmal D, Ram R, Kumar VS. Toxic Epidermal Necrolysis and Acute Kidney Injury due to Glyphosate Ingestion. Indian J Crit Care Med 2017; 21 (3):167-169.

DOI: 10.4103/ijccm.IJCCM_423_16

License: CC BY-ND 3.0

Published Online: 01-04-2018

Copyright Statement:  Copyright © 2017; The Author(s).


The literature, particularly from India, is scarce on the renal effects of glyphosate poisoning. Glyphosate causes toxicity not only after its ingestion but also after dermal exposure by inhalation route and on eye exposure. We present a patient report of glyphosate consumption which resulted in toxic epidermal necrolysis – the first report after glyphosate consumption and acute kidney injury.

PDF Share
  1. Bradberry SM, Proudfoot AT, Vale JA. Glyphosate poisoning. Toxicol Rev 2004;23:159-67.
  2. Mahendrakar K, Venkategowda PM, Rao SM, Mutkule DP. Glyphosate surfactant herbicide poisoning and management. Indian J Crit Care Med 2014;18:328-30.
  3. Han SK, Jeong J, Yeom S, Ryu J, Park S. Use of a lipid emulsion in a patient with refractory hypotension caused by glyphosate-surfactant herbicide. Clin Toxicol (Phila) 2010;48:566-8.
  4. Maibach HI. Irritation, sensitization, photoirritation and photosensitization assays with a glyphosate herbicide. Contact Dermatitis 1986;15:152-6.
  5. Amerio P, Motta A, Toto P, Pour SM, Pajand R, Feliciani C, et al. Skin toxicity from glyphosate-surfactant formulation. J Toxicol Clin Toxicol 2004;42:317-9.
  6. Temple WA, Smith NA. Glyphosate herbicide poisoning experience in New Zealand. N Z Med J 1992;105:173-4.
  7. Moon JM, Min YI, Chun BJ. Can early hemodialysis affect the outcome of the ingestion of glyphosate herbicide? Clin Toxicol (Phila) 2006;44:329-32.
  8. Stella J, Ryan M. Glyphosate herbicide formulation: A potentially lethal ingestion. Emerg Med Australas 2004;16:235-9.
  9. Lee HL, Chen KW, Chi CH, Huang JJ, Tsai LM. Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: A review of 131 cases. Acad Emerg Med 2000;7:906-10.
  10. Talbot A, Ku TS, Chen CL, Li GC, Li HP. Glyphosate levels in acute roundup herbicide poisoning. 1994 toxicology world congress abstracts. Ann Emerg Med 1995;26:717.
  11. Gil HW, Kim SJ, Yang JO, Lee EY, Hong SY. Clinical outcome of hemoperfusion in poisoned patients. Blood Purif 2010;30:84-8.
  12. Lee SH, Park SY, Kim S, Gil HW, Hong SY. Dialyzability of surfactants commonly used in pesticide formulations. J Clin Toxicol 2016;6:303.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.