Fecal carriage of extended-spectrum beta-lactamase-producing enterobacteriaceae in intensive care unit patients
Shalini Mulki, Kavya Ramamurthy, Sevitha Bhat
Keywords : Escherichia coli, extended-spectrum beta-lactamase, fecal carriage, Intensive Care Unit
Citation Information :
Mulki S, Ramamurthy K, Bhat S. Fecal carriage of extended-spectrum beta-lactamase-producing enterobacteriaceae in intensive care unit patients. Indian J Crit Care Med 2017; 21 (8):525-527.
Background and Aims: Increasing and indiscriminate use of antibiotics has led the bacteria to develop resistance to most of the antibiotics. Beta-lactamase production is the mechanism of resistance to beta-lactams. Extended-spectrum beta-lactamases (ESBLs) have been found in the members of Enterobacteriaceae such as Escherichia coli and Klebsiella spp. which are the common health-care-associated pathogens. The aim was to study the rate of fecal carriage of ESBL-producing Enterobacteriaceae in patients admitted to the Intensive Care Unit (ICU) of tertiary care hospital and follow them subsequently for the development of infections.
Materials and Methods: A hospital-based descriptive study was conducted in the department of microbiology of a tertiary care hospital for a period of 2 months from June 2016 to August 2016. Rectal swabs were collected from the patients admitted to the ICU after a period of 48 h. The swab was inoculated onto a special selective media (ChromID ESBL media). The results were noted according to the color of the colony produced. These patients are followed for the development of infection and the ESBL-producing organisms.
Results: A total of 60 rectal swabs were cultured, 39 (65%) showed a positive result. Out of which, 22 (56%) were ESBL-producing E. coli and 17 (43%) Klebsiella spp. Twenty-three (38%) of the total patients screened were infected with ESBL-producing organisms.
Conclusion: The study revealed high rates of carriage of ESBL producers in patients admitted to the ICU.
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