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VOLUME 21 , ISSUE 8 ( 2017 ) > List of Articles

CASE REPORT

Hemolytic-uremic syndrome complicating acute pancreatitis

Narinder Singh, Neeru P. Aggarwal, Hardik R. Shah, Laxmi Jha, Anish Kumar

Keywords : hemodialysis, plasmapheresis, thrombotic thrombocytopenic purpura,Acute kidney injury

Citation Information : Singh N, Aggarwal NP, Shah HR, Jha L, Kumar A. Hemolytic-uremic syndrome complicating acute pancreatitis. Indian J Crit Care Med 2017; 21 (8):534-536.

DOI: 10.4103/ijccm.IJCCM_121_17

License: CC BY-ND 3.0

Published Online: 00-08-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Hemolytic-uremic syndrome (HUS) is characterized by acute kidney injury with hemolytic anemia and thrombocytopenia. It has diverse etiologies, clinical manifestations, and risk factors. Acute pancreatitis as a cause of HUS is rare in adults. We report a case of 32-year-old male who presented with ethanol-induced acute pancreatitis complicated with hemolytic-uremic syndrome managed with hemodialysis and plasmapheresis.


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  1. Swisher KK, Doan JT, Vesely SK, Kwaan HC, Kim B, Lämmle B, et al. Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: Report of five patients with a systematic review of published reports. Haematologica 2007;92:936-43.
  2. Liu J, Hutzler M, Li C, Pechet L. Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS): The new thinking. J Thromb Thrombolysis 2001;11:261-72.
  3. Gasser C, Gautier E, Steck A, Siebenmann RE, Oechslin R. Hemolytic-uremic syndrome: Bilateral necrosis of the renal cortex in acute acquired hemolytic anemia. Schweiz Med Wochenschr 1955;85:905-9.
  4. Karpman D, Papadopoulou D, Nilsson K, Sjögren AC, Mikaelsson C, Lethagen S, et al. Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome. Blood 2001;97:3100-8.
  5. Tostivint I, Mougenot B, Flahault A, Vigneau C, Costa MA, Haymann JP, et al. Adult haemolytic and uraemic syndrome: Causes and prognostic factors in the last decade. Nephrol Dial Transplant 2002;17:1228-34.
  6. Remuzzi G. Hemolytic uremic syndrome: Past and present. Am J Kidney Dis 2000;36:LIV-VI.
  7. Silva VA. Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome secondary to pancreatitis. Am J Hematol 1995;50:53-6.
  8. Consonni R, Falanga A, Barbui T. Further characterization of platelet-aggregating cysteine proteinase activity in thrombotic thrombocytopenic purpura. Br J Haematol 1994;87:321-4.
  9. Furlan M, Robles R, Galbusera M, Remuzzi G, Kyrle PA, Brenner B, et al. Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. N Engl J Med 1998;339:1578-84.
  10. Chang JC, Kathula SK. Various clinical manifestations in patients with thrombotic microangiopathy. J Investig Med 2002;50:201-6.
  11. Gourley BL, Mesa H, Gupta P. Rapid and complete resolution of chemotherapy-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) with rituximab. Cancer Chemother Pharmacol 2010;65:1001-4.
  12. Prowle JR, Bellomo R. Continuous renal replacement therapy: Recent advances and future research. Nat Rev Nephrol 2010;6:521-9.
  13. Fu P, Yuan AH, Wang CH, Li X, Wu HY. Alcohol-induced severe acute pancreatitis followed by hemolytic uremic syndrome managed with continuous renal replacement therapy. BMC Nephrol 2014;15:1.
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