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VOLUME 22 , ISSUE 1 ( 2018 ) > List of Articles


Successful use of ketamine for burst suppression in super refractory status epilepticus following substance abuse

Dnyaneshwar P. Mutkule, Jaydip Chaudhuri, Kunche Rajasri

Keywords : Burst suppression, ketamine, status epilepticus

Citation Information : Mutkule DP, Chaudhuri J, Rajasri K. Successful use of ketamine for burst suppression in super refractory status epilepticus following substance abuse. Indian J Crit Care Med 2018; 22 (1):49-50.

DOI: 10.4103/ijccm.IJCCM_370_17

License: CC BY-ND 3.0

Published Online: 01-05-2018

Copyright Statement:  Copyright © 2018; The Author(s).


Status epilepticus is frequently encountered in neuro Intensive Care Units. It is a medical emergency and if not treated promptly can lead to severe brain damage and even death. Here, we present the case of a 18-year-old male with uncontrolled and unrelenting seizures with a rare etiology requiring ketamine infusion for burst suppression as it was resistant to thiopentone and midazolam infusions. The management of this case is presented in detail.

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  1. Brophy GM, Bell R, Claassen J, Alldredge B, Bleck TP, Glauser T, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care 2012;17:3-23.
  2. Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: A critical review of available therapies and a clinical treatment protocol. Brain 2011;134:2802-18.
  3. Shrestha GS, Joshi P, Chhetri S, Karn R, Acharya SP. Intravenous ketamine for treatment of super-refractory convulsive status epilepticus with septic shock: A report of two cases. Indian J Crit Care Med 2015;19:283-5.
  4. Bleck TP. Less common etiologies of status epilepticus. Epilepsy Curr 2010;10:31-3.
  5. Fang Y, Wang X. Ketamine for the treatment of refractory status epilepticus. Seizure 2015;30:14-20.
  6. Gaspard N, Foreman B, Judd LM, Brenton JN, Nathan BR, McCoy BM, et al. Intravenous ketamine for the treatment of refractory status epilepticus: A retrospective multicenter study. Epilepsia 2013;54:1498-503.
  7. Synowiec AS, Singh DS, Yenugadhati V, Valeriano JP, Schramke CJ, Kelly KM, et al. Ketamine use in the treatment of refractory status epilepticus. Epilepsy Res 2013;105:183-8.
  8. Ford BM, Tai S, Fantegrossi WE, Prather PL. Synthetic pot: Not your grandfather's marijuana. Trends Pharmacol Sci 2017;38:257-76.
  9. Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, et al. Cannabidiol in patients with treatment-resistant epilepsy: An open-label interventional trial. Lancet Neurol 2016;15:270-8.
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