Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 22 , ISSUE 10 ( 2018 ) > List of Articles

BRIEF COMMUNICATION

Diagnostic usefulness of serum albumin as a predictor of diabetic ketoacidosis

Jayagowri Karthikeyan, Sujatha Rajaragupathy

Keywords : Albumin, diabetes mellitus, ketoacidosis

Citation Information : Karthikeyan J, Rajaragupathy S. Diagnostic usefulness of serum albumin as a predictor of diabetic ketoacidosis. Indian J Crit Care Med 2018; 22 (10):733-736.

DOI: 10.4103/ijccm.IJCCM_91_18

License: CC BY-ND 3.0

Published Online: 01-10-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Context: Diabetes mellitus is one of the most prevalent diseases worldwide. One of the acute complications of diabetes mellitus is diabetic ketoacidosis. It becomes essential for the healthcare physicians to identify the individuals who are likely to be prone to the development of ketosis. Serum albumin levels may be a cost-effective and simple parameter to prognosticate the risk of ketosis. Aims: This study was done to find a relationship between serum albumin levels and ketonuria. Settings and Design: After ethical approval, this prospective case–control study was carried out in patients diagnosed as type-2 diabetes mellitus. Subjects and Methods: Serum albumin levels were measured by bromo cresol green method. Measurement of urine ketones was done manually using dipsticks, a semi-quantitative manual method. Statistical Analysis Used: Student\'s t-test was used to compare continuous variables and Chi-square test for categorical variables. Pearson\'s correlation was done to establish correlation. Results: In the normoalbuminemic group, 72% were ketones negative and only 28% had positive ketones in urine, while in the hypoalbuminemic group, 50.7% had negative urine ketones and 49.3% had positive ketonuria. The mean value for ketones in urine was 9.7 mg/dL in the hypoalbuminemic group, but it was only 4.3 mg/dL in the normoalbuminemic group. Pearson\'s correlation between serum albumin and urine ketone levels was performed and the r-value was found to be −0.305. Conclusions: Serum albumin levels may predict the occurrence of ketosis in diabetic patients.


PDF Share
  1. Holman RR. Preface – Diabetes prevention and management. Best Pract Res Clin Endocrinol Metab 2016;30:329.
  2. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87:4-14.
  3. Kao Y, Hsu CC, Weng SF, Lin HJ, Wang JJ, Su SB, et al. Subsequent mortality after hyperglycemic crisis episode in the non-elderly: A national population-based cohort study. Endocrine 2016;51:72-82.
  4. Liu B, Yu C, Li Q, Li L. Ketosis-onset diabetes and ketosis-prone diabetes: Same or not? Int J Endocrinol 2013;2013:821403.
  5. Du S, Yang X, Shi D, Su Q. Characteristics of type 2 diabetes with ketosis in Baoshan, Yunnan of China. J Diabetes Res 2016;2016:7854294.
  6. American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care 2017;40:S11-24.
  7. Cheng PC, Hsu SR, Cheng YC. Association between serum albumin concentration and ketosis risk in hospitalized individuals with type 2 diabetes mellitus. J Diabetes Res 2016;2016:1269706.
  8. Shah A, Afzal M. Prevalence of diabetes and hypertension and association with various risk factors among different Muslim populations of Manipur, India. J Diabetes Metab Disord 2013;12:52.
  9. Zaman FA, Borang A. Prevalence of diabetes mellitus amongst rural hilly population of North Eastern India and its relationship with associated risk factors and related co-morbidities. J Nat Sci Biol Med 2014;5:383-8.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.