Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  26 (2022)
Volume  25 (2021)
Volume  24 (2020)
Volume  23 (2019)
Volume  22 (2018)
Volume  21 (2017)
Volume  20 (2016)
Volume  19 (2015)
Volume  18 (2014)
Volume  17 (2013)
Volume  16 (2012)
Volume  15 (2011)
Volume  14 (2010)
Volume  13 (2009)
Volume  12 (2008)
Volume  11 (2007)
Volume  10 (2006)
Volume  9 (2005)
Volume  8 (2004)
Related articles

VOLUME 22 , ISSUE 2 ( 2018 ) > List of Articles

CASE REPORT

The Fondaparinux Paradox: Fondaparinux-Related Heparin-Induced Thrombocytopenia

Vishal Peshattiwar

Keywords : Fondaparinux, heparin-induced thrombocytopenia, thromboprophylaxis treatment

Citation Information : Peshattiwar V. The Fondaparinux Paradox: Fondaparinux-Related Heparin-Induced Thrombocytopenia. Indian J Crit Care Med 2018; 22 (2):116-118.

DOI: 10.4103/ijccm.IJCCM_189_17

License: CC BY-ND 3.0

Published Online: 01-02-2018

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Fondaparinux, a pentasaccharide administered for heparin-induced thrombocytopenia (HIT), can lead to the occurrence of thrombocytopenia. This patient underwent aortic stent graft placement for Salmonella paratyphi A-infected abdominal aortic aneurysm. Fondaparinux was administered for anticoagulation that led to a dramatic decline in his platelet counts. Investigations revealed HIT profile, PF4/heparin by particle gel immunoassay to be positive. Fondaparinux, a prescribed anticoagulant for HIT can paradoxically predispose to thrombocytopenia.

PDF Share
  1. Lobo B, Finch C, Howard A, Minhas S. Fondaparinux for the treatment of patients with acute heparin-induced thrombocytopenia. Thromb Haemost 2008;99:208-14.
  2. Warkentin TE, Cook RJ, Marder VJ, Sheppard JA, Moore JC, Eriksson BI, et al. Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin. Blood 2005;106:3791-6.
  3. Warkentin TE, Maurer BT, Aster RH. Heparin-induced thrombocytopenia associated with fondaparinux. N Engl J Med 2007;356:2653-5.
  4. Pistulli R, Oberle V, Figulla HR, Yilmaz A, Pfeifer R. Fondaparinux cross-reacts with heparin antibodies in vitro in a patient with fondaparinux-related thrombocytopenia. Blood Coagul Fibrinolysis 2011;22:76-8.
  5. Bhatt VR, Aryal MR, Shrestha R, Armitage JO. Fondaparinux-associated heparin-induced thrombocytopenia. Eur J Haematol 2013;91:437-41.
  6. Linkins LA, Bates SM, Lee AY, Heddle NM, Wang G, Warkentin TE, et al. Combination of 4Ts score and PF4/H-paGIA for diagnosis and management of heparin-induced thrombocytopenia: Prospective cohort study. Blood 2015;126:597-603.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.

We use cookies on this site to enhance your user experience.

By clicking any link on this page you are giving your consent for us to set cookies.