Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 22 , ISSUE 6 ( 2018 ) > List of Articles

CASE REPORT

Therapeutic Red Cell Exchange Transfusion as an Adjuvant Therapy for Management of Sickle Cell Crisis in Adults

Anand Bandachar Mamdapur, Maddani Shanmukhappa Sagar, R. Madhusudan, Mustafa Samir

Keywords : red cell exchange transfusion, sickle cell crisis,Intensive Care Unit

Citation Information : Mamdapur AB, Sagar MS, Madhusudan R, Samir M. Therapeutic Red Cell Exchange Transfusion as an Adjuvant Therapy for Management of Sickle Cell Crisis in Adults. Indian J Crit Care Med 2018; 22 (6):457-459.

DOI: 10.4103/ijccm.IJCCM_23_18

License: CC BY-ND 3.0

Published Online: 00-06-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Sickle cell crisis is an acute clinical condition, caused due to capillary occlusion by the deformed red blood cells, leading to vaso-occlusive status. Vaso-occlusion is an emergency condition requiring intensive care admission and carries a high mortality. Sickle cell crisis is usually managed with hydration, analgesics, and supportive care. Therapeutic red cell exchange transfusion is advised as an adjuvant, for the management of sickle cell crisis, and it is mainly practiced in the pediatric population. We report an adult case of sickle cell crisis managed with therapeutic red cell exchange transfusion in Intensive Care Unit and successful outcome in patient management.


PDF Share
  1. Yazdanbakhsh K, Ware RE, Noizat-Pirenne F. Red blood cell alloimmunization in sickle cell disease: Pathophysiology, risk factors, and transfusion management. Blood 2012;120:528-37.
  2. Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, et al. Management of sickle cell disease: Summary of the 2014 evidence-based report by expert panel members. JAMA 2014;312:1033-48.
  3. Agheli A, Khemani K, Kalavar M, Steier W, He Z. Red blood cell exchange transfusion, an underutilized effective and reliable therapeutic modality in sickle cell disease, reduces number of admissions and length of hospital stay. Blood 2008;112:4822.
  4. Schwartz J, Padmanabhan A, Aqui N, Balogun RA, Connelly-Smith L, Delaney M, et al. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the writing committee of the American society for apheresis: The seventh special issue. J Clin Apher 2016;31:149-62.
  5. Guru PK, O Horo JC, Lehrke HD, Winters JL, Wilson JW. Exchange transfusion for babesiosis when, how, and how long? Indian J Crit Care Med 2016;20:674-6.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.