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VOLUME 22 , ISSUE 7 ( 2018 ) > List of Articles

REVIEW ARTICLE

Acute leukoencephalopathy with restricted diffusion

Mahesh Kamate

Keywords : acute encephalopathy with biphasic seizures and restricted diffusion, magnetic resonance imaging brain Acute Leukoencephalopathy with Restricted Diffusion,Acute encephalopathy

Citation Information : Kamate M. Acute leukoencephalopathy with restricted diffusion. Indian J Crit Care Med 2018; 22 (7):519-523.

DOI: 10.4103/ijccm.IJCCM_139_18

License: CC BY-ND 3.0

Published Online: 00-07-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Treatment and outcome of children with acute encephalopathy depend on the cause, prompt treatment of the underlying cause, and use of adequate supportive measures. Many novel causes of acute encephalopathy are emerging where lumbar puncture, computed tomography of the head, and routine biochemical testing can be normal such as acute disseminated encephalomyelitis and febrile infection-related refractory epilepsy syndrome. Magnetic resonance imaging (MRI) plays an important role in the workup of children with acute leukoencephalopathy. Despite this in few cases, a correct diagnosis is not possible and novel conditions have been described in the last decade. One such condition is acute encephalopathy with biphasic seizures and restricted diffusion also called as acute leukoencephalopathy with restricted diffusion. Here, the routine MRI sequences such as T1, T2, and fluid-attenuated inversion recovery sequences can be normal. Here, we have reviewed the etiology, types, clinicoradiological features, and treatment of this condition.


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