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VOLUME 22 , ISSUE 7 ( 2018 ) > List of Articles


In vitro activity of fosfomycin against multidrug-resistant urinary and nonurinary gram-negative isolates

Subhrajyoti Sahu, Ashok Praharaj

Keywords : Fosfomycin, multidrug-resistant Gram-negative bacilli, urinary tract infection

Citation Information : Sahu S, Praharaj A. In vitro activity of fosfomycin against multidrug-resistant urinary and nonurinary gram-negative isolates. Indian J Crit Care Med 2018; 22 (7):533-536.

DOI: 10.4103/ijccm.IJCCM_67_18

License: CC BY-ND 3.0

Published Online: 01-03-2015

Copyright Statement:  Copyright © 2018; The Author(s).


Background: The era of multidrug-resistant (MDR) Gram-negative bacilli (GNB) has renewed interest in fosfomycin. Aim: The present study evaluated the in vitro activity of fosfomycin against MDR urinary and nonurinary GNB isolates. Materials and Methods: Fosfomycin susceptibility was carried out by agar dilution for a total of 279 (142 from urine and 137 from other samples) MDR-GNB. Disk diffusion was done for urinary isolates only. Results: Urinary tract isolates had a high degree of susceptibility to fosfomycin (overall susceptibility, 90.8%), whereas only 42.9% of nonurinary isolates retained susceptibility to the drug. Percentage susceptibility rates for urinary and nonurinary isolates of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter spp. were 99%, 91.3%, 66%, 0% and 62%, 44.4%, 32%, 11%, respectively. Conclusion: Fosfomycin showed excellent in vitro activity for uropathogens. Large-scale evaluation of fosfomycin against MDR systemic isolates is required to evaluate its therapeutic efficacy.

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