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VOLUME 22 , ISSUE 9 ( 2018 ) > List of Articles

CASE REPORT

Hepatitis A Virus-induced Severe Hemolysis Complicated by Severe Glucose-6-Phosphate Dehydrogenase Deficiency

Amit Goel, Shashank Shekhar, Omender Singh, Suneel Garg, Dhruva Sharma

Keywords : Glucose-6-phosphate dehydrogenase deficiency, hemolytic anemia, hemoperfusion, hepatitis A, methemoglobinemia, multiorgan failure

Citation Information : Goel A, Shekhar S, Singh O, Garg S, Sharma D. Hepatitis A Virus-induced Severe Hemolysis Complicated by Severe Glucose-6-Phosphate Dehydrogenase Deficiency. Indian J Crit Care Med 2018; 22 (9):670-673.

DOI: 10.4103/ijccm.IJCCM_260_18

License: CC BY-ND 3.0

Published Online: 00-09-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an x-linked recessive genetic disorder with mutation in the G6PD gene. Defect in the enzyme G6PD causes red blood cells (RBCs) to breakdown prematurely causing hemolytic anemia. Hemolytic anemia is also a known hematological complication associated with viral hepatitis. In such patients, hemolysis may be more severe if there is any secondary injury to RBC in the form of membrane defect, oxidative stress, or enzyme deficiency like in G6PD deficiency. Here, we present a case of an adult, not previously diagnosed with G6PD deficiency, who presented with viral hepatitis, severe hemolysis, and multiorgan failure.


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