Indian Journal of Critical Care Medicine

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VOLUME 23 , ISSUE 1 ( January, 2019 ) > List of Articles

BRIEF COMMUNICATION

Life-threatening Episodes of Malignant Hyperthermia Following Halothane Anesthesia in Three Children: A Case Series and Review of Literature

Keywords : Anaesthesia,Dantrolene,Halothane,Malignant hyperthermia,Ryanodine receptor

Citation Information : Life-threatening Episodes of Malignant Hyperthermia Following Halothane Anesthesia in Three Children: A Case Series and Review of Literature. Indian J Crit Care Med 2019; 23 (1):47-50.

DOI: 10.5005/jp-journals-10071-23112

License: CC BY-ND 3.0

Published Online: 01-01-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Malignant hyperthermia (MH) is an inherited, pharmacogenetic disorder of the skeletal muscle, characterized by dangerous hypermetabolic state after anaesthesia with succinylcholine and/ or volatile halogenated anesthetic agents, clinically manifested as hyperpyrexia and related complications like tachycardia, tachypnoea, increased carbon dioxide production, increased oxygen consumption, acidosis, rigid muscles, rhabdomyolysis and disseminated intravascular coagulation (DIC). Here we present a series of three cases of MH, admitted in our hospital in a span of 8 months for three different operative procedures to be done under general anaesthesia (Cleft lip repair, Duhamel’s operation for Hirschsprung’s disease and surgical repair of development dysplasia of hip), who developed probable hyperthermia owing to Halothane being used as an anaesthetic agent.


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