Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 23 , ISSUE 10 ( October, 2019 ) > List of Articles


Mystery of PCO2 Gap in Sepsis

Citation Information : Mystery of PCO2 Gap in Sepsis. Indian J Crit Care Med 2019; 23 (10):443-444.

DOI: 10.5005/jp-journals-10071-23260

License: CC BY-NC 4.0

Published Online: 01-08-2019

Copyright Statement:  Copyright © 2019; The Author(s).


PDF Share
  1. Helmy TA, El-Reweny EM, Ghazy FG. Prognostic value of venous to arterial carbon dioxide difference during early resuscitation in critically ill patients with septic shock. Indian J Crit Care Med. 2017;21(9):589–593.
  2. Araujo DT, Felice VB, Meregalli AF, Friedman G. The value of central venous to arterial CO2 difference after early goal directed therapy in septic shock patients. Indian J Crit Care Med 2019;23(10):449–453.
  3. McEvoy JD, Jones NL, Campbell EJ. Mixed venous and arterial Pco2. Br Med J 1974;4:687–690.
  4. Bakker J, Vincent JL, Gris P, Leon M, Coffernils M, Kahn RJ. Veno-arterial carbon dioxide gradient in human septic shock. Chest 1992;101;509–515.
  5. Cuschieri J, Rivers EP, Donnino MW, Katilius M, Jacobson G, Nguyen HB, et al. Central venous-arterial carbon dioxide difference as an indicator of cardiac index. Intensive Care Med 2005;31:818–822.
  6. van Beest PA, Lont MC, Holman ND, Loef B, Kuiper MA, Boerma EC. Central venous-arterial pCO2 difference as a tool in resuscitation of septic patients. Intensive Care Med. 2013 ;39(6):1034–1039.
  7. Ospina-Tascón GA, Bautista-Rincón DF, Umaña M, Tafur JD, Gutiérrez A, García AF, et al. Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock. Crit Care. 2013;17(6):R294.
  8. Mecher CE, Rackow EC, Astiz ME, Weil MH. Venous hypercarbia associated with severe sepsis and systemic hypoperfusion. Crit Care Med. 1990;18(6):585–589.
  9. Vallet B, Teboul JL, Cain S, Curtis S. Venoarterial CO2 difference during regional ischemic or hypoxic hypoxia. J Appl Physiol 1985 2000; 89:1317–1321.
  10. Nevière R, Chagnon JL, Teboul JL, Vallet B, Wattel F. Small intestine intramucosal PCO2 and microvascular blood flow during hypoxic and ischemic hypoxia. Crit Care Med 2002;30:379–384.
  11. Wendon JA, Harrison PM, Keays R, Gimson AE, Alexander G, Williams R. Arterial-venous pH differences and tissue hypoxia in patients with fulminant hepatic failure. Crit Care Med. 1991;19(11):1362–1364.
  12. Gutierrez G. A mathematical model of tissue-blood carbon dioxide exchange during hypoxia. Am J Respir Crit Care Med. 2004;169(4):525–533.
  13. Ruokonen E, Takala J, Kari A, Saxén H, Mertsola J, Hansen EJ. Regional blood flow and oxygen transport in septic shock. Crit Care Med. 1993;21(9):1296–1303.
  14. Levy B, Bollaert PE, Charpentier C, Nace L, Audibert G, Bauer P, et al. Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective, randomized study. Intensive Care Med. 1997;23(3):282–287.
  15. Muller G, Mercier E, Vignon P, Henry-Lagarrigue M, Kamel T, Desachy A, et al. Prognostic significance of central venous-to-arterial carbon dioxide difference during the first 24 hours of septic shock in patients with and without impaired cardiac function. Br J Anaesth 2017;119:239–248.
  16. Troskot R, Šimurina T, Žižak M, Majstorović K, Marinac I, Mrakovčić-Šutić I. Prognostic value of venoarterial carbon dioxide gradient in patients with severe sepsis and septic shock. Croat Med J 2010;51:501–508.
  17. Guinot PG, Badoux L, Bernard E, Abou-Arab O, Lorne E, Dupont H. Central venous-to-arterial carbon dioxide partial pressure difference in patients undergoing cardiac surgery is not related to postoperative outcomes. J Cardiothorac Vasc Anesth. 2017;31(4):1190-1196.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.