In case of multidrug resistant CNS infection use of intraventricular antibiotics are considered which have their own undesirable effects.1 An adult male patient who presented with multidrug resistant infection secondary to procedures done to facilitate to drain cerebrospinal fluid. Secondary to intraventricular antibiotic administration patient developed an intraparenchymal bleed with intraventricular extension; as a result of the bleed there was persistently raised intracranial pressure (ICP). The harmful effects of intraventricular antibiotics have to always be considered before taking a decision to start it. Appropriate precaution and low threshold of suspicion is required to rule out complications.
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