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VOLUME 23 , ISSUE 7 ( July, 2019 ) > List of Articles
Florence Benita, Narendra Nath Jena, Sambathkumar Sasikumar, Ponniah Thirumalaikolundusubramanian
Keywords : 5-oxoprolinuria, Metabolic acidosis, N-acetyl cysteine, Paracetamol therapy, Recovery, Risk/precipitating factors
Citation Information : Benita F, Jena NN, Sasikumar S, Thirumalaikolundusubramanian P. 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery. Indian J Crit Care Med 2019; 23 (7):342-343.
License: CC BY-NC 4.0
Published Online: 01-07-2019
Copyright Statement: Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.
A case of high anion gap metabolic acidosis (HAGMA) and high level of 5-oxoprolinuria were noticed in an elderly female of 66 years who had multiple risk/precipitating factors and recovered well with N-acetyl cysteine infusion. This is reported in view of its rarity and to create awareness of this entity among medical students and practicing physicians who handles such cases in emergency room or critical care unit. Moreover they have to remember and investigate the cases of metabolic acidosis for 5-oxoprolinuia especially in susceptible individuals who are on paracetamol with or without other precipitating factors.
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