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VOLUME 23 , ISSUE S1 ( Supplement-1 (January), 2019 ) > List of Articles
Karan Madan, Atul P Kulkarni, Anant Mohan
Citation Information : Madan K, Kulkarni A P, Mohan A. Guidelines for Antibiotic Prescription in Intensive Care Unit. Indian J Crit Care Med 2019; 23 (S1):1-63.
License: CC BY-NC 4.0
Published Online: 01-06-2018
Copyright Statement: Copyright © 2019; The Author(s).
Pharmacokinetics and Pharmacodynamics
Time-dependent antibiotics require drug concentrations greater than the minimum inhibitory concentration (MIC) for a certain period between doses, which usually ranges from 40 to 50% of the inter-dose interval for their best action. Continuous infusions are preferred over extended infusions for beta-lactam antibiotics and are associated with clinical benefits like a decrease in hospital stay, cost of therapy and mortality. For vancomycin, continuous infusion is associated with reduced toxicity and cost of therapy but no mortality benefit.