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VOLUME 23 , ISSUE S1 ( Supplement-1 (January), 2019 ) > List of Articles


Guidelines for Antibiotic Prescription in Intensive Care Unit

Karan Madan, Atul P Kulkarni, Anant Mohan

Citation Information : Madan K, Kulkarni A P, Mohan A. Guidelines for Antibiotic Prescription in Intensive Care Unit. Indian J Crit Care Med 2019; 23 (S1):1-63.

DOI: 10.5005/jp-journals-10071-23101

License: CC BY-NC 4.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2019; The Author(s).


Pharmacokinetics and Pharmacodynamics

Evidence Statement

Time-dependent antibiotics require drug concentrations greater than the minimum inhibitory concentration (MIC) for a certain period between doses, which usually ranges from 40 to 50% of the inter-dose interval for their best action. Continuous infusions are preferred over extended infusions for beta-lactam antibiotics and are associated with clinical benefits like a decrease in hospital stay, cost of therapy and mortality. For vancomycin, continuous infusion is associated with reduced toxicity and cost of therapy but no mortality benefit.

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